RIP3 Rabbit Polyclonal Antibody

Catalog number ER1902-12

Discontinued

Price for ER1902-12

Size / count 100 µL

This variant is discontinued and cannot be added to your cart.

About this product

Receptor-interacting serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the RIPK3 gene. The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Specifications

Catalog number: ER1902-12
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: Yes
CAS Number: 9007-83-4
Product Name Alternative: Receptor interacting protein 3 antibody Receptor interacting serine threonine kinase 3 antibody Receptor interacting serine/threonine protein kinase 3 antibody Receptor-interacting protein 3 antibody Receptor-interacting serine/threonine-protein kinase 3 antibody RIP 3 antibody RIP like protein kinase 3 antibody RIP-3 antibody RIP-like protein kinase 3 antibody RIPK 3 antibody RIPK3 antibody RIPK3_HUMAN antibody
Abbreviation: Receptor-interacting serine/threonine-protein kinase 3 RIP-like protein kinase 3 Receptor-interacting protein 3 RIP-3 mRIP3 Ripk3 Rip3
Swiss Prot: Q9QZL0 Mouse, Q9Z2P5 Rat
Cellular Locus: Mitochondrion, Cytosol, Plasma membrane.
Host: Rabbit
Species Reactivity: Mouse, Rat
Immunogen: Synthetic peptide within Mouse RIP3 aa 440-486 / 486.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB
Positive Control: MEF cell lysates.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:1,000
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 57 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for RIP3 Rabbit Polyclonal Antibody?

The catalog number for RIP3 Rabbit Polyclonal Antibody is ER1902-12.

Is RIP3 Rabbit Polyclonal Antibody in stock?

RIP3 Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is RIP3 Rabbit Polyclonal Antibody used for?

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.