PPAR delta Rabbit Polyclonal Antibody

About this product

PPARδ is a nuclear hormone receptor that governs a variety of biological processes and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer.In muscle PPAR-β/δ expression is increased by exercise, resulting in increased oxidative (fat-burning) capacity and an increase in type I fibers. Both PPAR-β/δ and AMPK agonists are regarded as exercise mimetics. In adipose tissue PPAR-β/δ increases both oxidation as well as uncoupling of oxidative phosphorylation.PPARδ may function as an integrator of transcription repression and nuclear receptor signaling. It activates transcription of a variety of target genes by binding to specific DNA elements. Well described target genes of PPARδ include PDK4, ANGPTL4, PLIN2, and CD36. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein involved in the APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, epidermal cell proliferation, and glucose and lipid metabolism.This protein has been shown to be involved in differentiation, lipid accumulation, directional sensing, polarization, and migration in keratinocytes.

Specifications

Catalog number

ER1902-24

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

FAAR antibody MGC3931 antibody NR1C2 antibody NUC1 antibody NUCI antibody NUCII antibody Nuclear hormone receptor 1 antibody Nuclear receptor subfamily 1 group C member 2 antibody Peroxisome proliferative activated receptor delta antibody Peroxisome proliferator-activated receptor beta (PPAR-beta) antibody Peroxisome proliferator-activated receptor beta antibody Peroxisome proliferator-activated receptor delta antibody PPAR beta antibody PPAR-beta antibody PPAR-delta antibody PPAR-ß antibody PPARB antibody ppard antibody PPARD_HUMAN antibody

Abbreviation

PPAR-delta,Peroxisome proliferator-activated receptor delta,NUCI,Nuclear hormone receptor 1,NUC1,Nuclear receptor subfamily 1 group C member 2,Peroxisome proliferator-activated receptor beta,PPAR-beta,PPARD

Swiss Prot

Q03181 Human, P35396 Mouse

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant protein within human PPARD aa 260-441.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, FC

Positive Control

Mouse colon tissue lysates, SHSY5Y.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1000 ;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 50 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No