Factor XIIIa Rabbit Polyclonal Antibody

About this product

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.

Specifications

Catalog number

ER1902-34

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

bA525O21.1 (coagulation factor XIII, A1 polypeptide) antibody Coagulation factor XIII A chain antibody Coagulation factor XIII A1 polypeptide antibody Coagulation factor XIII A1 subunit antibody Coagulation factor XIII, A polypeptide antibody Coagulation factor XIIIa antibody F13A antibody F13A_HUMAN antibody F13a1 antibody Factor XIIIA antibody Fibrin stabilizing factor, A subunit antibody Fibrinoligase antibody FSF, A subunit antibody Protein glutamine gamma glutamyltransferase A chain antibody Protein-glutamine gamma-glutamyltransferase A chain antibody TGase antibody Transglutaminase A chain antibody Transglutaminase, plasma antibody Transglutaminase. plasma antibody

Abbreviation

Coagulation factor XIII A chain ,Coagulation factor XIIIa,Protein-glutamine gamma-glutamyltransferase A chain Transglutaminase A chain,F13A1

Swiss Prot

P00488 Human

Cellular Locus

Cytoplasm, Secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human Factor XIIIa aa 259-463 / 732.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

Human placenta tissue lysate, human liver tissue lysate, human placenta tissue, Hela.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 83 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No