IL-17A Rabbit Polyclonal Antibody

About this product

Interleukin 17A (IL-17 or IL-17A) is a pro-inflammatory cytokine. This cytokine is produced by a group of T helper cell known as T helper 17 cell in response to their stimulation with IL-23. Originally, Th17 was identified in 1993 by Rouvier et al. who isolated IL17 transcript from a rodent T-cell hybridoma. The protein encoded by IL17A is a founding member of IL-17 family (see below). IL17 protein exhibits a high homology with a viral IL-17-like protein encoded in the genome of T-lymphotropic rhadinovirus Herpesvirus saimiri.[2] In rodents, IL-17 is often referred to as CTLA8.The biologically active IL-17 interacts with type I cell surface receptor IL-17R. In turn, there are at least three variants of IL-17R referred to as IL17RA, IL17RB, and IL17RC. After binding to the receptor, IL-17 activates several signalling cascades that, in turn, lead to the induction of chemokines. Acting as chemoattractants, these chemokines recruit the immune cells, such as monocytes and neutrophils to the site of inflammation. Typically, the signaling events mentioned above follow an invasion of the body by pathogens. Promoting the inflammation, IL-17 acts in concert with tumor necrosis factor and interleukin-1.Moreover, an activation of IL-17 signalling is often observed in the pathogenesis of various autoimmune disorders, such as psoriasis.

Specifications

Catalog number

ER1902-37

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

CTLA 8 antibody CTLA-8 antibody CTLA8 antibody Cytotoxic T lymphocyte associated antigen 8 antibody Cytotoxic T lymphocyte associated protein 8 antibody Cytotoxic T lymphocyte associated serine esterase 8 antibody Cytotoxic T-lymphocyte-associated antigen 8 antibody IL 17A antibody IL-17 antibody IL-17A antibody IL17 antibody IL17_HUMAN antibody Il17a antibody Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8) antibody Interleukin 17A antibody Interleukin-17A antibody Interleukin17 antibody Interleukin17A antibody OTTHUMP00000016597 antibody OTTMUSP00000046003 antibody

Abbreviation

Interleukin-17A,IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8,IL17A

Swiss Prot

Q16552 Human, Q62386 Mouse

Cellular Locus

Secreted.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human IL17 aa 1-155 / 155.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

Recombinant protein lysates, Rat stomach tissue lysates, Human skeletal muscle tissue lysate, human fetal skeletal muscle tissue, human esophagus tissue, mouse colon tissue, Jurkat.

Concentration

1 mg/mL

Dilution

WB: 1:500 ;IHC-P: 1:50-1:800 ;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 18 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No