Kv1.4 Rabbit Polyclonal Antibody

About this product

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure . Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation .

Specifications

Catalog number

ER1902-49

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Voltage gated K+ channel HuKII antibody Fetal skeletal muscle potassium channel antibody HBK4 antibody HK1 antibody HPCN2 antibody HUKII antibody Kcna4 antibody KCNA4_HUMAN antibody KCNA4L antibody KCNA8 antibody kv1.4 antibody PCN2 antibody Potassium channel 2 antibody Potassium voltage gated channel shaker related subfamily member 4 antibody Potassium voltage gated channel subfamily A member 4 antibody Potassium voltage-gated channel subfamily A member 4 antibody Rapidly inactivating potassium channel antibody Shaker related potassium channel Kv1.4 antibody Type A potassium channel antibody Voltage gated potassium channel HBK4 antibody Voltage gated potassium channel HK1 antibody Voltage gated potassium channel subunit Kv1.4 antibody Voltage-gated K (+) channel HuKII antibody Voltage-gated potassium channel HBK4 antibody Voltage-gated potassium channel HK1 antibody Voltage-gated potassium channel subunit Kv1.4 antibody

Abbreviation

Potassium voltage-gated channel subfamily A member 4 RCK41 RHK1 RK3 Voltage-gated potassium channel subunit Kv1.4 Kcna4

Swiss Prot

P22459 Human, Q61423 Mouse, P15385 Rat

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within mouse KCNA4 aa 330-379 / 654.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, IF-Cell, FC

Positive Control

Rat brain tissuet lysates, rat cerebellar tissue, MCF-7, PANC-1, mouse brain.

Concentration

1 mg/mL

Dilution

WB: 1:500;IHC-P: 1:50-1:200;IHC-P: 1:50-1:200;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

73 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No