LGR5 Rabbit Polyclonal Antibody

About this product

G protein-coupled receptors (GPCRs), also designated seven transmembrane (7TM) receptors or heptahelical receptors, interact with G proteins (heterotrimeric GTPases) to synthesize intracellular second messengers, such as diacylglycerol, cyclic AMP, inositol phosphates and calcium ions. Their diverse biological functions range from vision and olfaction to neuronal and endocrine signaling and are involved in many pathological conditions. LGR5 (leucine-rich repeat-containing G-protein coupled receptor 5), also known as GPR49 or GPR67, is a 907 amino acid multi-pass membrane protein that contains 17 leucine-rich repeats and belongs to the G protein-coupled receptor family. Expressed in placenta, skeletal muscle and spinal cord, LGR5 functions as an orphan receptor that is thought to play an important role in embryonic growth control and cellular differentiation. Overexpression of LGR5 is associated with increased tumor susceptibility and malignant transformation, implicating LGR5 as a potent tumor-inducing protein.

Specifications

Catalog number

ER1902-52

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

FEX antibody G protein coupled receptor 49 antibody G protein coupled receptor 67 antibody g protein-coupled receptor fex antibody G-protein coupled receptor 49 antibody G-protein coupled receptor 67 antibody G-protein coupled receptor HG38 antibody GPCR GPR49 antibody GPR 49 antibody GPR 67 antibody GPR49 antibody GPR67 antibody GRP 49 antibody GRP49 antibody HG 38 antibody HG38 antibody Leucine rich repeat containing G protein coupled receptor 5 antibody Leucine-rich repeat-containing G-protein coupled receptor 5 antibody LGR 5 antibody LGR5 antibody LGR5_HUMAN antibody MGC117008 antibody Orphan G protein coupled receptor HG38 antibody

Abbreviation

Leucine-rich repeat-containing G-protein coupled receptor 5 G-protein coupled receptor 49 G-protein coupled receptor 67 G-protein coupled receptor HG38 LGR5 GPR49 GPR67

Swiss Prot

O75473 Human

Cellular Locus

Cell membrane, Golgi apparatus.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human LGR5 aa 499-548 / 907.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB

Positive Control

293 cell lysate, NIH/3T3 cell lysate, HCT116.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 100 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No