CD95 Rabbit Polyclonal Antibody

About this product

Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immuno-surveillance against virus-infected or transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FAS-based mechanism involves the transducing molecule FAS (also designated APO-1) and its ligand (FAS-L). The human FAS protein is a cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, certain of which undergo apoptosis in response to treatment with antibody to FAS. These findings strongly imply that targeted cell death is potentially mediated by the intercellular interactions of FAS with its ligand or effectors, and that FAS may be critically involved in CTL-mediated cytotoxicity.

Specifications

Catalog number

ER1902-56

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

ALPS 1A antibody ALPS1A antibody APO 1 antibody Apo 1 antigen antibody APO 1 cell surface antigen antibody Apo-1 antigen antibody APO1 antibody Apo1 antigen antibody APO1 cell surface antigen antibody Apoptosis antigen 1 antibody Apoptosis mediating surface antigen FAS antibody Apoptosis-mediating surface antigen FAS antibody APT 1 antibody APT1 antibody CD 95 antibody CD 95 antigen antibody CD95 antibody CD95 antigen antibody Delta Fas antibody Delta Fas/APO 1/CD95 antibody Delta Fas/APO1/CD95 antibody Fas (TNF receptor superfamily, member 6) antibody FAS 1 antibody FAS 827dupA antibody Fas AMA antibody Fas antibody FAS Antigen antibody Fas cell surface death receptor antibody FAS1 antibody FASLG receptor antibody FASTM antibody sFAS antibody Surface antigen APO1 antibody TNF receptor superfamily, member 6 antibody TNFRSF 6 antibody TNFRSF6 antibody TNR6_HUMAN antibody Tumor necrosis factor receptor superfamily member 6 antibody

Abbreviation

Tumor necrosis factor receptor superfamily member 6,Apo-1 antigen,Apoptosis-mediating surface antigen FAS,FASLG receptor,CD95,FAS

Swiss Prot

P25445 Human

Cellular Locus

Cell membrane, Membrane, Secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within C-terminal human CD95.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, FC

Positive Control

Daudi cell lysates, A431 cell.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

38 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No