SynGAP Rabbit Polyclonal Antibody

About this product

Synaptic Ras GTPase-activating protein 1, also known as synaptic Ras-GAP 1 or SYNGAP1, is a protein that in humans is encoded by the SYNGAP1 gene. SYNGAP1 is a ras GTPase-activating protein that is critical for the development of cognition and proper synapse function. Mutations in humans can cause intellectual disability or epilepsy. SynGAP1 is a complex protein with several functions that may be regulated temporally via complex isoforms. A well-documented function of SynGAP1 involves NMDA receptor-mediated synaptic plasticity and membrane insertion of AMPA receptors through the suppression of upstream signaling pathways. However, SynGAP1 has also been shown to function cooperatively with Unc51.1 in axon formation. One way SynGAP1 affects these processes is through the MAP kinase signaling pathway by attenuation of Ras signalling. However, alternative splicing and multiple translational start sites have been shown to cause opposing effects, illustrating the importance of multiple functional domains that reside within the c- and n-termini. For example, the expression of an α1 or α2 c-terminal variant of SynGAP1 will either increase or decrease synaptic strength, respectively. Overall, SynGAP1 is essential for development and survival, which is evident as knockout mice die perinatally.

Specifications

Catalog number

ER1902-57

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

DKFZp761G1421 antibody KIAA1938 antibody MRD5 antibody Neuronal RasGAP antibody OTTHUMP00000064825 antibody p135 SynGAP antibody Ras GTPase activating protein SynGAP antibody Ras GTPase-activating protein SynGAP antibody RASA 1 antibody RASA 5 antibody RASA1 antibody RASA5 antibody SYGP1_HUMAN antibody Synaptic Ras GAP 1 antibody Synaptic Ras GTPase activating protein 1 antibody Synaptic Ras GTPase activating protein 1 homolog antibody Synaptic Ras GTPase activating protein 135kDa antibody Synaptic Ras GTPase activating protein antibody Synaptic Ras GTPase-activating protein 1 antibody Synaptic Ras-GAP 1 antibody SYNGAP 1 antibody SYNGAP1 antibody

Abbreviation

Ras/Rap GTPase-activating protein SynGAP,Neuronal RasGAP,Synaptic Ras GTPase-activating protein 1, Synaptic Ras-GAP 1,YNGAP1

Swiss Prot

Q96PV0 Human, Q9QUH6 Rat, F6SEU4 Mouse

Cellular Locus

Cytosol.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human SynGAP aa 1100-1250.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

K562 cell lysate, mouse brain tissue lysate, human terus tissue, mouse brain tissue, SW620.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:50-1:100 ;FC:1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

148 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No