DNMT3A Rabbit Polyclonal Antibody — image 1 of 3

Product details

DNMT3A Rabbit Polyclonal Antibody

Catalog number ER1902-62

Price for ER1902-62

Size / count 100 µL

About this product

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.

Specifications

Catalog number: ER1902-62
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: DNA (cytosine 5) methyltransferase 3 alpha antibody DNA (cytosine 5) methyltransferase 3A antibody DNA (cytosine-5)-methyltransferase 3A antibody DNA cytosine methyltransferase 3A2 antibody DNA methyltransferase 3 alpha antibody DNA methyltransferase 3a antibody DNA methyltransferase HsaIIIA antibody DNA MTase HsaIIIA antibody DNM3A_HUMAN antibody DNMT 3a antibody DNMT antibody Dnmt3a antibody DNMT3A2 antibody M.HsaIIIA antibody MCMT antibody OTTHUMP00000201149 antibody TBRS antibody
Abbreviation: DNMT3A
Swiss Prot: Q9Y6K1 Human, O88508 Mouse, Q1LZ53 Rat
Cellular Locus: Nucleus, cytoplasm.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein within human DNMT3A aa 1-300.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB, IHC-P, FC
Positive Control: Hela cell lysates, rat large intestine tissue, human tonsil tissue, human breast carcinoma tissue, human kidney tissue, human fetal skeletal muscle tissue, mouse brain tissue, SH-SY5Y.
Concentration: 1 mg/mL
Dilution: WB:1:500-1:2,000 ;IHC-P:1:50-1:200 ;FC:1:50-1:100
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size 102 kDa.
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for DNMT3A Rabbit Polyclonal Antibody?

The catalog number for DNMT3A Rabbit Polyclonal Antibody is ER1902-62.

What sizes are available for DNMT3A Rabbit Polyclonal Antibody?

DNMT3A Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is DNMT3A Rabbit Polyclonal Antibody in stock?

DNMT3A Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is DNMT3A Rabbit Polyclonal Antibody used for?

What is the immunogen used to generate this antibody?

Immunogen or antigen details used to raise this antibody are listed on the product datasheet under immunogen information.

What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.