CDK5RAP3 Rabbit Polyclonal Antibody

About this product

Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation . Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation . Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation . May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress . May also play a role in the rupture of the nuclear envelope during apoptosis . May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1

Specifications

Catalog number

ER1902-72

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

C53 antibody CDK5 activator binding protein C53 antibody CDK5 activator-binding protein C53 antibody CDK5 regulatory subunit associated protein 3 antibody CDK5 regulatory subunit-associated protein 3 antibody Cdk5rap3 antibody CK5P3_HUMAN antibody HSF 27 antibody HSF27 antibody IC53 antibody Ischemic heart CDK5 activator binding protein C53 antibody LXXLL/leucine zipper containing ARFbinding protein antibody LZAP antibody MST016 antibody OK/SW cl.114 antibody PP1553 antibody Protein HSF-27 antibody

Abbreviation

CDK5 regulatory subunit-associated protein ,CDK5 activator-binding protein C53 LXXLL/leucine-zipper-containing ARF-binding protein Protein HSF-27 CDK5RAP3

Swiss Prot

Q96JB5 Human

Cellular Locus

Cytoplasm, Cytoskeleton, Nucleus.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human CDK5RAP3 aa 296-506 / 506.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, FC

Positive Control

MCF-7 cell lysates, LOVO, PC-3M, SHSY5Y.

Concentration

1 mg/mL

Dilution

WB: 1:500;IF-Cell: 1:50-1:200;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size 57 kDa.

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No