Thymidine Phosphorylase Rabbit Polyclonal Antibody

About this product

Recent research has found that thymidine phosphorylase is also involved in angiogenesis. Experiments show inhibition of angiogenic effect by thymidine phosphorylase in the presence of 6-amino-5-chlorouracil, an inhibitor of thymidine phosphorylase, suggesting that the enzymatic activity of thymidine phosphorylase is required for its angiogenic activity. Thymidine phosphorylase has been determined to be almost identical to the platelet-derived endothelial cell growth factor (PD-ECGF). Although the mechanism of angiogenesis by thymidine phosphorylase is not yet known, reports show that the enzyme itself is not a growth factor but indirectly causes angiogenesis by stimulating chemotaxis of endothelial and other cells. Some reports suggest that thymidine phosphorylase promotes endothelial cell growth by reducing levels of thymidine that would otherwise inhibit endothelial cell growth. An alternative explanation is that the enzyme’s products induce angiogenesis. Experiments have found that 2-deoxyribose is an endothelial-cell chemoattractant and angiogenesis-inducing factor, which supports this explanation.Research has found thymidine phosphorylase is involved in angiogenesis during the menstrual cycle. The enzyme's expression in the endometrium is raised by a combination of progesterone and transforming growth factor-β1 and varies over the course of the menstrual cycle.

Specifications

Catalog number

ER1902-79

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

ECGF 1 antibody ECGF antibody ECGF1 antibody Endothelial cell growth factor 1 antibody Endothelial cell growth factor 1 platelet derived antibody Endothelial cell growth factor, platelet-derived antibody Gliostatin antibody hPD ECGF antibody MEDPS1 antibody MNGIE antibody MTDPS1 antibody PD ECGF antibody PD-ECGF antibody PDECGF antibody PDEGF antibody Platelet derived endothelial cell growth factor antibody Platelet derived endothelial growth factor antibody Platelet-derived endothelial cell growth factor antibody TdRPase antibody Thymidine phosphorylase antibody TP antibody Tymp antibody TYPH_HUMAN antibody

Abbreviation

Thymidine phosphorylase TYMP TP Gliostatin Platelet-derived endothelial cell growth factor PD-ECGF TdRPas

Swiss Prot

P19971 Human

Cellular Locus

Cytosol.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human Thymidine Phosphorylase aa 19-239 / 482.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

SKBR-3 cell lysates, human appendix tissue, human tonsil tissue, human liver cancer tissue, Siha.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:50-1:400 ;FC:1:100-1:200

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size 50 kDa.

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No