Foxk2 Rabbit Polyclonal Antibody

About this product

Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy . Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context . Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen . Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 . Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate . Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins . In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (By similarity). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (By similarity). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (By similarity). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (By similarity).

Specifications

Catalog number

ER2001-47

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Cellular transcription factor ILF 1 antibody Cellular transcription factor ILF-1 antibody Cellular transcription factor ILF1 antibody Forkhead box K2 antibody Forkhead box protein K2 antibody FOX K1 antibody FOX K2 antibody FOXK 1 antibody FOXK 2 antibody FOXK1 antibody foxk2 antibody FOXK2_HUMAN antibody ILF 1 antibody ILF antibody Interleukin enhancer binding factor 1 antibody Interleukin enhancer-binding factor 1 antibody

Abbreviation

Forkhead box protein K2Curated Cellular transcription factor ILF-11 Interleukin enhancer-binding factor 1

Swiss Prot

Q01167 Human, Q3UCQ1 Mouse

Cellular Locus

Cytoplasm, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within mouse Foxk2 aa 1-350.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

293 cell lysates, mouse lung tissue, mouse colon tissue, mouse brain tissue, SHSY5Y.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000;IHC-P: 1:200-1:1,000;FC: 1:50-1:200

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

68 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No