GADD34 Rabbit Polyclonal Antibody

About this product

Protein phosphatase 1 regulatory subunit 15A also known as growth arrest and DNA damage-inducible protein GADD34 is a protein that in humans is encoded by the PPP1R15A gene. The Gadd34/MyD116 gene was originally discovered as a member in a set of gadd and MyD mammalian genes encoding acidic proteins that synergistically suppress cell growth. Later on it has been characterized as a gene playing a role in ER stress-induced cell death, being a target of ATF4 that plays a role in ER-mediated cell death via promoting protein dephosphorylation of eIF2α and reversing translational inhibition. This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation.

Specifications

Catalog number

ER2001-56

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Apoptosis associated protein antibody GADD 34 antibody Growth arrest and DNA damage inducible 34 antibody Growth arrest and DNA damage-inducible protein GADD34 antibody Myeloid differentiation primary response protein MyD116 homolog antibody Ppp1r15a antibody PR15A_HUMAN antibody Protein phosphatase 1 regulatory (inhibitor) subunit 15A antibody Protein phosphatase 1 regulatory subunit 15A antibody

Abbreviation

Protein phosphatase 1 regulatory subunit 15A Growth arrest and DNA damage-inducible protein GADD34 Myeloid differentiation primary response protein MyD116 homolog

Swiss Prot

O75807 Human

Cellular Locus

Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human GADD34 aa 1-50.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

HepG2 cell lysate, A431 cell lysate, human skin tissue, human prostate carcinoma tissue, human placenta tissue, K562.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000;IHC-P: 1:50-1:1200;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 73 kDa.

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No