IKK alpha Rabbit Polyclonal Antibody

About this product

Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans is encoded by the CHUK gene. IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor. However, IKK-α has many additional cellular targets, and is thought to function independently of the NF-κB pathway to regulate epidermal differentiation. Inhibition of IκB kinase (IKK) and IKK-related kinases, IKBKE (IKKε) and TANK-binding kinase 1 (TBK1), has been investigated as a therapeutic option for the treatment of inflammatory diseases and cancer. Mutations in IKK-α in humans have been linked to lethal fetal malformations. The phenotype of these mutant fetuses is similar to the mouse IKK-α null phenotype, and is characterized by shiny, thickened skin and truncated limbs. Decreased IKK-α activity has been reported in a large percentage of human squamous cell carcinomas, and restoring IKK-α in mouse models of skin cancer has been shown to have an anti-tumorigenic effect.

Specifications

Catalog number

ER30911

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

chuk antibody CHUK1 antibody Conserved Helix Loop Helix Ubiquitous Kinase antibody Conserved helix loop ubiquitous kinase antibody Conserved helix-loop-helix ubiquitous kinase antibody I Kappa B Kinase 1 antibody I Kappa B Kinase Alpha antibody I-kappa-B kinase 1 antibody I-kappa-B kinase alpha antibody IkappaB kinase antibody IkB kinase alpha subunit antibody IkBKA antibody IKK 1 antibody IKK A antibody IKK a kinase antibody IKK-A antibody IKK-alpha antibody IKK1 antibody IKKA antibody IKKA_HUMAN antibody Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells antibody Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit antibody Inhibitor of nuclear factor kappa-B kinase subunit alpha antibody NFKBIKA antibody Nuclear Factor Kappa B Inhibitor Kinase Alpha antibody Nuclear factor NF kappa B inhibitor kinase alpha antibody Nuclear factor NF-kappa-B inhibitor kinase alpha antibody Nuclear factor NFkappaB inhibitor kinase alpha antibody Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor antibody TCF-16 antibody TCF16 antibody Transcription factor 16 antibody

Abbreviation

I-kappa-B kinase alpha,IKK-A,IKK-alpha,IkBKA,IkappaB kinase,IKK1,NFKBIKA,TCF-16

Swiss Prot

O15111 Human

Cellular Locus

Cytoplasm, nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human Ikk alpha aa 1-50 / 745.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

HeLa cell lysate, HCT 116 cell lysate, SK-OV-3 cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, mouse kidney tissue lysate, rat kidney tissue lysate, N2A, human mammary gland tissue, human gastric carcinoma tissue.

Concentration

1 mg/mL

Dilution

WB: 1:2,000 ;IF-Cell: 1:200 ;IHC-P: 1:200

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 85 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No