PBR Recombinant Rabbit Monoclonal Antibody [SA90-03]

About this product

Translocator protein (TSPO) is an 18 kDa protein mainly found on the outer mitochondrial membrane. It was first described as peripheral benzodiazepine receptor (PBR), a secondary binding site for diazepam, but subsequent research has found the receptor to be expressed throughout the body and brain. In humans, the translocator protein is encoded by the TSPO gene. It belongs to a family of tryptophan-rich sensory proteins. Regarding intramitochondrial cholesterol transport, TSPO has been proposed to interact with StAR (steroidogenic acute regulatory protein) to transport cholesterol into mitochondria, though evidence is mixed. In animals, TSPO (PBR) is a mitochondrial protein usually located in the outer mitochondrial membrane and characterised by its ability to bind a variety of benzodiazepine-like drugs, as well as to dicarboxylic tetrapyrrole intermediates of the haem biosynthetic pathway. TSPO has many proposed functions depending on the tissue. The most studied of these include roles in the immune response, steroid synthesis and apoptosis.

Specifications

Catalog number

ET1601-19

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Benzodiazapine receptor (peripheral) antibody Benzodiazepine peripheral binding site antibody BPBS antibody BZRP antibody DBI antibody IBP antibody Isoquinoline carboxamide-binding protein antibody MBR antibody mDRC antibody Mitochondrial benzodiazepine receptor antibody PBR antibody PBS antibody Peripheral benzodiazepine receptor antibody Peripheral benzodiazepine receptor-related protein antibody Peripheral type benzodiazepine receptor antibody Peripheral-type benzodiazepine receptor antibody pk18 antibody PKBS antibody PTBR antibody Ptbzr antibody PTBZR02 antibody RATPTBZR02 antibody translocator protein (18kDa) antibody Translocator protein antibody Tspo antibody Tspo1 antibody TSPOA_HUMAN antibody

Abbreviation

PBR, TSPO

Swiss Prot

P30536 Human, P50637 Mouse, P16257 Rat

Cellular Locus

Mitochondrion membrane

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human PBR aa 120-169 / 169.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP, FC

Positive Control

HCT 116 cell lysate, THP-1 cell lysate, 293T cell lysate, SK-OV-3 cell lysate, NIH/3T3 cell lysate, RAW264.7 cell lysate, PC-12 cell lysates, THP-1, human colon tissue, human kidney tissue, mouse colon tissue, mouse kidney tissue, human colon carcinoma tissue, human prostate carcinoma tissue.

Concentration

1 mg/mL

Dilution

WB: 1:2,000 ;IF-Cell: 1:1,000 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:400-1:1,000 ;FC: 1:1,000 ;IP: 1-2μg/sample

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 19 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes