Collagen XVII Recombinant Rabbit Monoclonal Antibody [SR46-05]

About this product

Collagen XVII, previously called BP180, is a transmembrane protein which plays a critical role in maintaining the linkage between the intracellular and the extracellular structural elements involved in epidermal adhesion. COL17A1 is the official name of the gene. It encodes the alpha chain of type XVII collagen. Collagen XVII is a transmembrane protein, like collagen XIII, XXIII and XXV. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. It also appears to be a key protein in maintaining the integrity of the corneal epithelium.[5] Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa,[6] as well as recurrent corneal erosions, and expression of this gene is abnormal in various cancers. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form.

Specifications

Catalog number

ET1602-14

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9000-83-3

Product Name Alternative

180 kDa bullous pemphigoid antigen 2 antibody Alpha 1 type XVII collagen antibody BA16H23.2 antibody BP 180 antibody BP180 antibody BPA 2 antibody BPAG 2 antibody BPAG2 antibody Bullous pemphigoid antigen 2 antibody COL17A1 antibody Collagen 17 antibody Collagen alpha 1 XVII chain antibody Collagen alpha 1 (XVII) chain antibody Collagen alpha1 XVII chain antibody Collagen type XVII alpha 1 antibody Collagen XVII alpha 1 polypeptide antibody CollagenXVII antibody Epidermolysis bullosa junctional localisata variant antibody FLJ60881 antibody KIAA0204 antibody LAD 1 antibody LAD1 antibody

Abbreviation

COL17A1

Swiss Prot

Q9UMD9 Human, Q07563 Mouse

Cellular Locus

Cell junction, Membrane, Secreted

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human Collagen XVII aa 1313-1420 / 1497.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP

Positive Control

A431 cell lysate, mouse skin tissue lysate, rat skin tissue lysate, HUVEC, human skin tissue, mouse skin tissue, rat skin tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;IF-Cell: 1:50 ;IF-Tissue: 1:50 ;IHC-P: 1:50-1:200 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 148 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes