Cytokeratin 17 Recombinant Rabbit Monoclonal Antibody [SR45-06]

About this product

Cytokeratin 17 is a member of the Cytokeratin subfamily of intermediate filament proteins (IFPs). It is unique in that it is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Cytokeratin 17 contains 432 amino acids and is expressed in the nail bed, hair follicle, sebaceous glands and other epidermal appendages. Cytokeratin 17 functions to regulate cell growth and size through its interactions with the adaptor protein 14-3-3-sigma to mediate protein synthesis. Mutations in the gene encoding for Cytokeratin 17 lead to depressed protein translation and smaller sized skin keratinocytes, corresponding to decreased Akt/mTOR signaling activity. Cytokeratin 17 may be a useful marker for cervical stem cell identification, squamous cell carcinoma of the larynx, respiratory syncytial virus and transitional cell carcinomas of the human urinary tract.

Specifications

Catalog number

ET1602-16

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

39.1 antibody CK 17 antibody CK17 antibody CK-17 antibody Cytokeratin-17 antibody K17 antibody K1C17_HUMAN antibody Keratin 17 antibody keratin 17 epitope S1 antibody keratin 17 epitope S2 antibody keratin 17 epitope S4 antibody Keratin 17, type I antibody Keratin antibody Keratin type I cytoskeletal 17 antibody keratin, type i cytoskeletal 17 [version 1] antibody Keratin-17 antibody KRT17 antibody PC antibody PC2 antibody PCHC1 antibody type I cytoskeletal 17 antibody

Abbreviation

CK-17, K17

Swiss Prot

Q04695 Human, Q9QWL7 Mouse, Q6IFU8 Rat

Cellular Locus

Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human Cytokeratin 17 aa 1-50 / 432.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P

Positive Control

A431 cell lysates, Mouse skin tissue lysate, Rat skin tissue lysate, SiHa, human prostate tissue, human skin tissue, human tonsil tissue, mouse prostate tissue, human cervical carcinoma tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:2,000 ;IF-Cell: 1:50 ;IF-Tissue: 1:200 ;IHC-P: 1:50-1:1,500

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 48 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes