DUSP6 Recombinant Rabbit Monoclonal Antibody [SR39-09]

About this product

Dual specificity phosphatase 6 (DUSP6) is an enzyme that in humans is encoded by the DUSP6 gene. The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas and, unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. Upregulation of MKP-3 has been shown to alleviate chronic postoperative pain.

Specifications

Catalog number

ET1602-18

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Dual specificity phosphatase 6 antibody Dual specificity phosphatase 6 isoform a antibody Dual specificity protein phosphatase 6 antibody Dual specificity protein phosphatase PYST1 antibody DUS6_HUMAN antibody DUSP 6 antibody DUSP 6a antibody Dusp6 antibody DUSP6a antibody HH19 antibody MAP kinase phosphatase 3 antibody Mitogen activated protein kinase phosphatase 3 antibody Mitogen-activated protein kinase phosphatase 3 antibody MKP 3 antibody MKP-3 antibody MKP3 antibody PYST 1 antibody PYST1 antibody Serine/threonine specific protein phosphatase antibody

Abbreviation

MAP kinase phosphatase 3, MKP-3

Swiss Prot

Q16828 Human, Q9DBB1 Mouse, Q64346 Rat

Cellular Locus

Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human DUSP6 aa 325-381 / 381.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Tissue, IHC-P, IP

Positive Control

HepG2 cell lysate, RAW264.7 cell lysate, C6 cell lysate, Human lung tissue lysate, Mouse brain tissue lysate, Rat brain tissue lysate, human pancreas tissue, mouse pancreas tissue, human gastric carcinoma tissue, mouse brain tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IF-Tissue: 1:50 ;IHC-P: 1:200-1:1,000 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 42 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes