SHP1 Recombinant Rabbit Monoclonal Antibody [SR41-02]

About this product

Tyrosine-protein phosphatase non-receptor type 6, also known as Src homology region 2 domain-containing phosphatase-1 (SHP-1), is an enzyme that in humans is encoded by the PTPN6 gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling, (e.g., the LYN-CD22-SHP-1 pathway). Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

Specifications

Catalog number

ET1602-19

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9000-83-3

Product Name Alternative

70Z-SHP antibody EC 3.1.3.48 antibody HCP antibody HCPH antibody Hematopoietic cell phosphatase antibody Hematopoietic cell protein tyrosine phosphatase antibody Hematopoietic cell protein-tyrosine phosphatase antibody HPTP1C antibody Protein tyrosine phosphatase 1C antibody Protein tyrosine phosphatase non receptor type 6 antibody Protein tyrosine phosphatase SHP1 antibody Protein-tyrosine phosphatase 1C antibody protein-tyrosine phosphatase SHP 1 antibody Protein-tyrosine phosphatase SHP-1 antibody PTN6_HUMAN antibody PTP 1C antibody PTP-1C antibody PTP1C antibody Ptpn6 antibody SH PTP 1 antibody SH PTP1 antibody SH-PTP1 antibody SHP 1 antibody SHP 1L antibody SHP1 antibody SHP1L antibody tyrosine protein phosphatase non receptor type 6 antibody Tyrosine-protein phosphatase non-receptor type 6 antibody

Abbreviation

PTP-1C

Swiss Prot

P29350 Human, P29351 Mouse, P81718 Rat

Cellular Locus

Cytoplasm, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human SHP1 aa 537-595 / 595.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, FC

Positive Control

Jurkat cell lysate, RAW264.7 cell lysate, Mouse spleen tissue lysate, Rat thymus tissue lysate, Jurkat, RAW264.7, human tonsil tissue, mouse spleen tissue, rat brain tissue, rat spleen tissue, mouse brain tissue.

Concentration

1 mg/mL

Dilution

WB: 1:2,000-1:5,000 ;IF-Cell: 1:1,000 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:200-1:1,000 ;FC: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 68 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes