CCR7 Recombinant Rabbit Monoclonal Antibody [SR36-04]

About this product

C-C chemokine receptor type 7 is a protein that in humans is encoded by the CCR7 gene. Two ligands have been identified for this receptor: the chemokines (C-C motif) ligand 19 (CCL19/ELC) and (C-C motif) ligand 21 (CCL21). CCR7 has also recently been designated CD197 (cluster of differentiation 197). The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. CCR7 has been shown to stimulate dendritic cell maturation. CCR7 is also involved in homing of T cells to various secondary lymphoid organs such as lymph nodes and the spleen as well as trafficking of T cells within the spleen. Activation of Dendritic cells in peripheral tissues induces CCR7 expression on the cell's surface, which recognize CCL19 and CCL21 produced in the Lymph node and increases dendritic cell expression of co-stimulation molecules (B7), and MHC class I or MHC class II.

Specifications

Catalog number

ET1602-22

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9000-83-3

Product Name Alternative

BLR 2 antibody BLR2 antibody C C chemokine receptor type 7 antibody C C CKR 7 antibody C-C chemokine receptor type 7 antibody C-C CKR-7 antibody CC chemokine receptor 7 antibody CC chemokine receptor type 7 antibody CC CKR 7 antibody CC-CKR-7 antibody CCCKR7 antibody CCR 7 antibody CCR-7 antibody Ccr7 antibody CCR7_HUMAN antibody CD 197 antibody CD197 antibody CD197 antigen antibody CDw197 antibody Chemokine (C C motif) receptor 7 antibody Chemokine (C C) receptor 7 antibody Chemokine C C motif receptor 7 antibody Chemokine C C receptor 7 antibody Chemokine receptor 7 antibody Chemokine receptor 7-like protein antibody CMKBR7 antibody EBI 1 antibody EBI1 antibody Ebi1h antibody EBV Induced G Protein Coupled Receptor 1 antibody EBV-induced G-protein coupled receptor 1 antibody Epstein Barr virus induced G protein coupled receptor antibody Epstein Barr virus induced gene 1 antibody Epstein-Barr virus-induced G-protein coupled receptor 1 antibody EVI 1 antibody EVI1 antibody Lymphocyte Specific G Protein Coupled Peptide Receptor antibody MGC108519 antibody MIP 3 beta receptor antibody MIP-3 beta receptor antibody MIP3 Beta Receptor antibody

Abbreviation

C-C CKR-7, CC-CKR-7, CCR-7, EBI1, EBV-induced G-protein coupled receptor 1

Swiss Prot

P32248 Human, P47774 Mouse

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human CCR7 aa 13-62 / 378.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP

Positive Control

HDLM-2 cell lysate, Jurkat cell lysate, Daudi cell lysate, MCF7 cell lysate, mouse spleen tissue lysate, mouse pancreas tissue lysate, rat spleen tissue lysate, Raji cell lysate, EL4 cell lysate, RAW264.7 cell lysate, C6 cell lysate, Daudi, RAW264.7, C6, human tonsil tissue, human spleen tissue.

Concentration

1 mg/mL

Dilution

WB: 1:2,000-1:5,000 ;IF-Cell: 1:200-1:500 ;IF-Tissue: 1:200 ;IHC-P: 1:200 ;IP: 1-2μg/sample

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 43 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes