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![PUMA Recombinant Rabbit Monoclonal Antibody [SR42-09] — image 1 of 3](https://cdn.genprice.uk/products/992/68dd1c8d061270361ea82035/imageurl/et1602-24.webp)
Product details
Catalog number ET1602-24
Price for ET1602-24
Size / count 100 µL
The p53 upregulated modulator of apoptosis (PUMA) also known as Bcl-2-binding component 3 (BBC3), is a pro-apoptotic protein, member of the Bcl-2 protein family. In humans, the Bcl-2-binding component 3 protein is encoded by the BBC3 gene. The expression of PUMA is regulated by the tumor suppressor p53. PUMA is involved in p53-dependent and -independent apoptosis induced by a variety of signals, and is regulated by transcription factors, not by post-translational modifications. After activation, PUMA interacts with antiapoptotic Bcl-2 family members, thus freeing Bax and/or Bak which are then able to signal apoptosis to the mitochondria. Following mitochondrial dysfunction, the caspase cascade is activated ultimately leading to cell death.
The catalog number for PUMA Recombinant Rabbit Monoclonal Antibody [SR42-09] is ET1602-24.
PUMA Recombinant Rabbit Monoclonal Antibody [SR42-09] is available in the following size(s): 100 µL.
PUMA Recombinant Rabbit Monoclonal Antibody [SR42-09] is currently made to order / not held in immediate stock. Contact us for lead time.
The p53 upregulated modulator of apoptosis (PUMA) also known as Bcl-2-binding component 3 (BBC3), is a pro-apoptotic protein, member of the Bcl-2 protein family. In humans, the Bcl-2-binding component 3 protein is encoded by the BBC3 gene. The expression of PUMA is regulated by the tumor suppressor
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Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.
Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.
