p38 alpha/MAPK14 Recombinant Rabbit Monoclonal Antibody [SR43-04]

About this product

p38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation, apoptosis and autophagy. Persistent activation of the p38 MAPK pathway in muscle satellite cells (muscle stem cells) due to ageing, impairs muscle regeneration. p38 MAP Kinase (MAPK), also called RK or CSBP (Cytokinin Specific Binding Protein), is the mammalian orthologue of the yeast Hog1p MAP kinase, which participates in a signaling cascade controlling cellular responses to cytokines and stress. Four p38 MAP kinases, p38-α (MAPK14), -β (MAPK11), -γ (MAPK12 / ERK6), and -δ (MAPK13 / SAPK4), have been identified. Similar to the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), ultraviolet light, and growth factors. MKK3 and SEK activate p38 MAP kinase by phosphorylation at Thr-180 and Tyr-182.

Specifications

Catalog number

ET1602-26

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CSAID Binding Protein 1 antibody CSAID binding protein antibody CSAID-binding protein antibody Csaids binding protein antibody CSBP 1 antibody CSBP 2 antibody CSBP antibody CSBP1 antibody CSBP2 antibody CSPB1 antibody Cytokine suppressive anti-inflammatory drug-binding protein antibody EXIP antibody MAP kinase 14 antibody MAP kinase MXI2 antibody MAP kinase p38 alpha antibody MAPK 14 antibody MAPK14 antibody MAX interacting protein 2 antibody MAX-interacting protein 2 antibody Mitogen Activated Protein Kinase 14 antibody Mitogen activated protein kinase p38 alpha antibody Mitogen-activated protein kinase 14 antibody Mitogen-activated protein kinase p38 alpha antibody MK14_HUMAN antibody Mxi 2 antibody MXI2 antibody p38 ALPHA antibody p38 antibody p38 MAP kinase antibody p38 MAPK antibody p38 mitogen activated protein kinase antibody p38ALPHA antibody p38alpha Exip antibody PRKM14 antibody PRKM15 antibody RK antibody SAPK2A antibody

Abbreviation

MAP kinase 14, MAPK 14, CSAID-binding protein, CSBP, MAP kinase p38 alpha, SAPK2a

Swiss Prot

Q16539 Human, P47811 Mouse, P70618 Rat

Cellular Locus

Cytoplasm, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within human p38 aa 160-200.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, FC

Positive Control

Hela cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, THP-1 cell lysate, Jurkat cell lysate, C2C12 cell lysate, rat kidney tissue lysate, mouse kidney tissue lysate, HeLa, RAW264.7, C6.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IF-Cell: 1:100-1:500 ;IF-Tissue: 1:50 ;FC: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 41 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes