IFNAR1 Recombinant Rabbit Monoclonal Antibody [SR45-08]

About this product

The type I interferons (IFNs), α and β, are a group of structurally and functionally related proteins that are induced by either viruses or double stranded RNA and defined by their ability to confer an antiviral state in cells. The α and β IFNs appear to compete with one another for binding to a common cell surface receptor, while immune IFN (IFNγ) binds to a distinct receptor. The latter protein, IFN-αR, is only weakly responsive to type I interferons in contrast to IFN-α/βR, which binds to and responds effectively to IFN-β and to several of the IFN-? subtypes. Moreover, IFN-α/βR is physically associated with the cytoplasmic tyrosine kinase JAK1 and thus, in addition to ligand binding, appears to be functionally involved in signal transduction. IFN-αR1 is a receptor for IFN-α/β and is present as the full chain (IFN-αR1a) and as a splice-variant (IFN-αR1). The IFN-γ receptor complex consists of an alpha subunit (IFN-γRα) and a beta subunit that is 332 amino acids in length (mouse) and 337 amino acids in length (human).

Specifications

Catalog number

ET1602-37

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9000-83-3

Product Name Alternative

Alpha type antiviral protein antibody AVP antibody Beta type antiviral protein antibody CRF2-1 antibody Cytokine receptor class-II member 1 antibody Cytokine receptor family 2 member 1 antibody IFN alpha REC antibody IFN alpha receptor antibody IFN alpha/beta Receptor alpha antibody IFN beta receptor antibody IFN-alpha/beta receptor 1 antibody IFN-R-1 antibody IFNAR antibody Ifnar1 antibody IFNBR antibody IFRC antibody INAR1_HUMAN antibody Interferon (alpha beta and omega) receptor 1 antibody Interferon alpha/beta receptor 1 antibody Interferon alpha/beta receptor alpha chain antibody Interferon beta receptor 1 antibody Type I interferon receptor 1 antibody

Abbreviation

IFN-R-1, IFN-alpha/beta receptor 1, CRF2-1

Swiss Prot

P17181 Human, P33896 Mouse, D3ZDS9 Rat

Cellular Locus

Cell membrane, Late endosome, Lysosome.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human IFNAR1 aa 508-557 / 557.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC, IP, ICC

Positive Control

HeLa cell lysate, Jurkat cell lysate, K-562 cell lysate, human tonsil tissue, rat brain tissue, mouse brain tissue, Jurkat.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IHC-P: 1:50-1:200 ;FC: 1:50 ;IP: Use at an assay dependent concentration. ;ICC: 1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 64 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes