Survivin Recombinant Rabbit Monoclonal Antibody [SR44-02]

About this product

Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis .Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis .Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules.Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis.The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules .May counteract a default induction of apoptosis in G2/M phase .The acetylated form represses STAT3 transactivation of target gene promoters.May play a role in neoplasia. Inhibitor of CASP3 and CASP7.Essential for the maintenance of mitochondrial integrity and function.

Specifications

Catalog number

ET1602-43

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

API4 antibody Apoptosis inhibitor 4 antibody Apoptosis inhibitor survivin antibody Apoptosis inhibitor4 antibody Baculoviral IAP repeat containing 5 antibody Baculoviral IAP repeat containing protein 5 antibody Baculoviral IAP repeat-containing protein 5 antibody BIRC 5 antibody BIRC5 antibody BIRC5_HUMAN antibody EPR 1 antibody IAP4 antibody Survivin variant 3 alpha antibody SVV antibody TIAP antibody

Abbreviation

Birc5

Swiss Prot

O70201 Mouse, Q9JHY7 Rat

Cellular Locus

Cytoplasm, Nucleus, Chromosome, Midbody.

Host

Rabbit

Species Reactivity

Mouse, Rat

Immunogen

Full length recombinant protein within mouse Survivin.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IP

Positive Control

L929 cell lysate, F9 cell lysate, rat spleen tissue, mouse testis tissue, mouse colon tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:2,000 ;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 16 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes