M6PR Recombinant Rabbit Monoclonal Antibody [SR45-09]

About this product

The mannose 6-phosphate/insulin-like growth factor II receptor, IGF-IIR (also designated M6P/IGF2R), is a ubiquitously expressed integral glycoprotein. By binding glycoproteins through two of its extracytoplasmic domains, IGF-IIR mediates the activation of TGF∫1 (a growth inhibitor), the degradation of IGF-II and the transport of lysosomal enzymes. Subsequently, IGF-IIR can form oligomeric complexes, which increase the affinity of IGF-IIR for lysosomal enzymes. Unlike IGF-IR, IGF-IIR does not potentiate the signaling of IGF-I or IGF-II, which have mitogenic, cell survival and insulin-like effects. Therefore, IGF-IIR is characterized as a tumor suppressor. Furthermore, the IGF-IIR gene is located on chromosome 6q26, which is commonly mutated or deleted in several human cancers.

Specifications

Catalog number

ET1602-5

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

300 kDa mannose 6 phosphate receptor antibody 300 kDa mannose 6-phosphate receptor antibody Cation independent mannose 6 phosphate receptor antibody Cation-independent mannose-6-phosphate receptor antibody CD222 antibody CD222 antigen antibody CI Man 6 P receptor antibody CI Man-6-P receptor antibody CI MPR antibody CI-M6PR antibody CI-MPR antibody CIMPR antibody IGF 2 receptor antibody IGF 2R antibody IGF II receptor antibody IGF-II receptor antibody IGF2 receptor antibody Igf2r antibody Insulin like growth factor 2 receptor antibody Insulin like growth factor II receptor antibody Insulin-like growth factor 2 receptor antibody Insulin-like growth factor II receptor antibody M6P R antibody M6P/IGF2 receptor antibody M6P/IGF2R antibody M6PR antibody mannose 6 phosphate receptor antibody mannose 6 phosphate receptor, cation independent antibody MPR 300 antibody MPR300 antibody MPRI antibody MPRI_HUMAN antibody

Abbreviation

CI Man-6-P receptor, CI-MPR, M6PR, MPR 300, IGF-II receptor, M6P/IGF2R

Swiss Prot

P11717 Human, Q07113 Mouse,

Cellular Locus

Golgi apparatus membrane, Endosome membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human M6PR aa 2,442-2,491 / 2,491.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP, FC

Positive Control

HeLa cell lysate, SK-OV-3 cell lysate, SiHa cell lysate, SK-MEL-28 cell lysate, NIH/3T3 cell lysate, C6 cell lysate, PC-12 cell lysate, HeLa, NIH/3T3, C6, human liver tissue, human tonsil tissue, mouse colon tissue, rat colon tissue.

Concentration

1 mg/mL

Dilution

WB: 1:2,000-1:10,000 ;IF-Cell: 1:100-1:250 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:200 ;FC: 1:1,000 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 274 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes