Olig2 Recombinant Rabbit Monoclonal Antibody [SP07-02]

About this product

The oligodendrocyte lineage-specific basic helix-loop-helix (OLIG) family of transcription factors include OLIG1-OLIG3, which differ in tissue expression. OLIG1 and OLIG2 are specifically expressed in nervous tissue as gene regulators of oligodendrogenesis. OLIG2 is more widely expressed in embryonic brain than OLIG1, while OLIG3 is primarily expressed in non-neural tissues. OLIG1 and OLIG2 interact with the Nkx-2.2 homeodomain protein, which is responsible for directing ventral neuronal patterning in response to graded Sonic hedgehog signaling in the embryonic neural tube. These interactions between OLIG proteins and Nkx-2.2 appear to promote the formation of alternate cell types by inhibiting V3 interneuron development. OLIG1 and OLIG2 are abundantly expressed in oligodendroglioma and nearly absent in astrocytomas. Therefore, OLIG proteins are candidates for molecular markers of human glial brain tumors, which are the most common primary malignancies of the human brain.

Specifications

Catalog number

ET1604-29

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Basic domain helix loop helix protein class B 1 antibody Basic helix loop helix protein class B 1 antibody BHLHB antibody bHLHB1 antibody bHLHe19 antibody Class B basic helix loop helix protein 1 antibody Class B basic helix-loop-helix protein 1 antibody class E basic helix loop helix protein 19 antibody Class E basic helix-loop-helix protein 19 antibody Human protein kinase C binding protein RACK17 antibody Olig2 antibody OLIG2_HUMAN antibody Oligo2 antibody Oligodendrocyte lineage transcription factor 2 antibody Oligodendrocyte specific bHLH transcription factor 2 antibody Oligodendrocyte transcription factor 2 antibody OTTHUMP00000067569 antibody OTTHUMP00000067570 antibody PRKCBP2 antibody Protein kinase C binding protein 2 antibody Protein kinase C binding protein RACK17 antibody Protein kinase C-binding protein 2 antibody Protein kinase C-binding protein RACK17 antibody RACK17 antibody

Abbreviation

Oligo2, bHLHb1, bHLHe19, OLIG2

Swiss Prot

Q13516 Human, Q9EQW6 Mouse

Cellular Locus

Nucleus, Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human Olig2 aa 238-287 / 323.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IHC-Fr, IF-Tissue, mIHC, IF-Cell

Positive Control

Mouse brain tissue lysate, rat brain tissue lysate, human brain tissue lysate, mouse cerebral cortex tissue, human glioma tissue, human brain tissue, rat brain tissue, mouse brain tissue, mouse hippocampus tissue, E14.5 mouse embryonic brain tissue, mouse glial cells.

Concentration

1 mg/mL

Dilution

WB: 1:5,000 ;IHC-P: 1:1,000 ;IHC-Fr: 1:500 ;IF-Tissue: 1:200 ;mIHC: 1:1,000-1:5,000 ;IF-Cell: 1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 32 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes