MLH1 Recombinant Rabbit Monoclonal Antibody [SP08-04] — image 1 of 3

Product details

MLH1 Recombinant Rabbit Monoclonal Antibody [SP08-04]

Catalog number ET1604-41

Discontinued

Price for ET1604-41

Size / count 100 µL

This variant is discontinued and cannot be added to your cart.

About this product

DNA-mismatch repair (MMR) is an essential process in maintaining genetic stability. Lack of a functional DNA-mismatch repair pathway is a common characteristic of several different types of human cancers, either due to an MMR gene mutation or promoter methylation gene silencing. MLH1 is an integral part of the protein complex responsible for mismatch repair and is expressed in lymphocytes, heart, colon, breast, lung, spleen, testis, prostate, thyroid and gall bladder tissues, and is methylated in several ovarian tumors. Loss of MLH1 protein expression is associated with a mutated phenotype, microsatellite instability and a predisposition to cancer. In hereditary nonpolyposis colorectal cancer (HNPCC), an autosomal dominant inherited cancer syndrome that signifies a high risk of colorectal and various other types of cancer, the MLH1 gene exhibits a pathogenic mutation. Certain cancer cell lines, including leukemia CCRF-CEM, colon HCT 116 and KM12, and ovarian cancers SK-OV-3 and IGROV-1, show complete deficiency of MLH1, while MLH1 is expressed in 60% of melanomas, 70% of noninvasive squamous cell carcinomas and 30% of invasive squamous cell carcinomas.

Specifications

Catalog number: ET1604-41
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: Yes
CAS Number: 9000-83-3
Product Name Alternative: COCA 2 antibody COCA2 antibody DNA mismatch repair protein Mlh1 antibody FCC 2 antibody FCC2 antibody hMLH 1 antibody hMLH1 antibody HNPCC 2 antibody HNPCC antibody HNPCC2 antibody MGC5172 antibody MLH 1 antibody MLH1 antibody MLH1_HUMAN antibody MutL homolog 1 (E. coli) antibody MutL homolog 1 antibody MutL homolog 1 colon cancer nonpolyposis type 2 antibody MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) antibody MutL protein homolog 1 antibody MutL, E. coli, homolog of, 1 antibody
Abbreviation: MLH1
Swiss Prot: P40692 Human, Q9JK91 Mouse, P97679 Rat
Cellular Locus: Nucleus.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide within Human MLH1 aa 707-756 / 756.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IF-Cell, IF-Tissue, IHC-P
Positive Control: B16F10 cell lysate, HeLa cell lysate, A549 cell lysate, MCF7 cell lysate, HepG2 cell lysate, HepG2, rat large intestine tissue, human tonsil tissue, mouse testis tissue, Hela.
Concentration: 1 mg/mL
Dilution: WB: 1:5,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200 ;IF-Tissue: 1:50-1:200
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 85 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for MLH1 Recombinant Rabbit Monoclonal Antibody [SP08-04]?

The catalog number for MLH1 Recombinant Rabbit Monoclonal Antibody [SP08-04] is ET1604-41.

Is MLH1 Recombinant Rabbit Monoclonal Antibody [SP08-04] in stock?

MLH1 Recombinant Rabbit Monoclonal Antibody [SP08-04] is currently made to order / not held in immediate stock. Contact us for lead time.

What is MLH1 Recombinant Rabbit Monoclonal Antibody [SP08-04] used for?

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.

Does this product need any special customs documentation to be imported to my country?

If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.

What buffer is this product supplied in?

The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.