PDGF Receptor beta Recombinant Rabbit Monoclonal Antibody [SY10-08]

About this product

Platelet-derived growth factor (PDGF) is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PGDF-AA, PDGF-AB and PDGF-BB. These three isoforms bind with different affinities to two receptor types, PDGFR-α and –β, which are endowed with protein tyrosine kinase domains. PDGFR-α can bind to both A and B subunits of PDGF, while PDGFR-β can only bind the B subunit. Ligand binding promotes either homo- or heterodimerization of the PDGF receptors in a specific manner. PDGF-AA induces the dimerization of two α receptors, PDGF-AB induces dimerization of αα and αβ and PDGF-BB induces the formation of three types of dimers, αα, αβ and ββ. Translocation of the PDGFR-∫ gene with the Tel gene is linked to chronic myelomonocytic leukemia (CMML), a myelodysplastic syndrome, and demonstrates the oncogenic potential of the PDGF receptors.

Specifications

Catalog number

ET1605-20

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Beta platelet derived growth factor receptor antibody Beta-type platelet-derived growth factor receptor antibody CD 140B antibody CD140 antigen-like family member B antibody CD140b antibody CD140b antigen antibody IBGC4 antibody IMF1 antibody JTK12 antibody OTTHUMP00000160528 antibody PDGF R beta antibody PDGF-R-beta antibody PDGFR 1 antibody PDGFR antibody PDGFR beta antibody PDGFR1 antibody PDGFRB antibody PGFRB_HUMAN antibody Platelet derived growth factor receptor 1 antibody Platelet derived growth factor receptor beta antibody Platelet derived growth factor receptor beta polypeptide antibody

Abbreviation

PDGF-R-beta, PDGFR-beta, PDGFR-1, PDGFRB

Swiss Prot

P05622 Mouse, P09619 Human, Q05030 Rat

Cellular Locus

Cell membrane, Cytoplasmic vesicle, Lysosome lumen.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human PDGF Receptor beta aa 961-1,106 / 1,106.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IP, FC, IF-Tissue, IF-Cell

Positive Control

NIH/3T3 cell lysates, human lung tissue, human spleen tissue, mouse lung tissue, mouse brain tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200 ;FC: 1:1,000 ;IF-Tissue: 1:200 ;IF-Cell:: 1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size:123 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes