SHIP Recombinant Rabbit Monoclonal Antibody [SY11-08]

About this product

The major translational product of the v-Fms oncogene, originally isolated from the McDonough strain of feline sarcoma virus, has been identified as a glycoprotein with intrinsic tyrosine kinase activity. The v-Fms human cellular homolog, c-Fms, has been molecularly cloned and mapped to band q34 on chromosome 5, and identified as the receptor for hematopoietic ligand, CSF-1. Ligand-induced activation of the intrinsic CSF-1R protein tyrosine kinase triggers its interaction with cytoplasmic effector molecules. One such effector molecule, SHIP-1 p145 (SH2-containing-inositol phosphatase), associates with activated Fms. SHIP-1 contains two phosphotyrosine-binding domains (PTB), a unique amino terminal SH2 domain, a proline-rich region, and two highly conserved motifs found among inositol phosphate 5-phosphatases. SHIP-1 displays both phosphatidylinositol 3,4,5-triphosphate and inositol 1,3,4,5-tetrakisphosphate polyphosphate 5-phosphatase activity. Evidence suggests that SHIP-1 may modulate Ras signaling in addition to inositol signaling pathways.

Specifications

Catalog number

ET1605-30

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Inositol polyphosphate 5 phosphatase of 145kDa antibody 4 antibody 5-trisphosphate 5-phosphatase 1 antibody hp51CN antibody Inositol polyphosphate 5 phosphatase 145kDa antibody Inositol polyphosphate 5 phosphatase antibody Inositol polyphosphate-5-phosphatase of 145 kDa antibody INPP5D antibody MGC104855 antibody MGC142140 antibody MGC142142 antibody p150Ship antibody Phosphatidylinositol 3,4,5 trisphosphate 5 phosphatase 1 antibody Phosphatidylinositol-3 antibody SH2 containing inositol phosphatase isoform b antibody SH2 domain containing inositol 5' phosphatase 1 antibody SH2 domain containing inositol phosphatase 1 antibody SH2 domain-containing inositol phosphatase 1 antibody SH2 domain-containing inositol-5'-phosphatase 1 antibody SHIP-1 antibody SHIP1 antibody SHIP1_HUMAN antibody Signaling inositol polyphosphate 5 phosphatase SIP 145 antibody SIP-145 antibody SIP145 antibody

Abbreviation

SIP-145, SH2 domain-containing inositol phosphatase 1, SHIP-1, hp51CN, INPP5D, SHIP, SHIP1

Swiss Prot

Q92835 Human

Cellular Locus

Cytoskeleton, Cell membrane, Cytoplasm, Membrane raft, Membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human SHIP aa 1,064-1,189 / 1,189.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IP, FC

Positive Control

HL-60 cell lysate, Daudi cell lysate, human tonsil tissue, human spleen tissue, Raji.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 133 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes