STAT6 Recombinant Rabbit Monoclonal Antibody [SY13-09]

About this product

Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of proteins that have been designated Stats (signal transducers and activators of transcription). The first members of this family to be described include Stat1α p91, Stat1β p84 (a form of p91 that lacks 38 COOH-terminal amino acids) and Stat2 p113. Stat1 and Stat2 are induced by IFN-a and form a heterodimer which is part of the ISGF3 transcription factor complex. Stat3, which becomes activated in response to epidermal growth factor (EGF) and interleukin-6 (IL-6), but not interferon-γ (IFN-γ) or Stat4, is an additional member of this family. It has been suggested that the phosphorylated forms of both Stat3 and Stat4 form homodimers as well as heterodimers with the other members of the Stat family, and that differential activation of different Stat proteins in response to different ligands should help to explain specificity in nuclear signaling from the cell surface. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Other members of the Stat family include Stat5, which has been shown to be activated by prolactin and by IL-3, and Stat6 (also designated IL-4 Stat), which is involved in IL-4-activated signaling pathways.

Specifications

Catalog number

ET1605-49

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

12S1644 antibody D12S1644 antibody IL 4 STAT antibody IL-4 Stat antibody IL4 STAT antibody Interleukin 4 Induced antibody Interleukin 4 Induced Transcription Factor IL4 STAT antibody Signal transducer and activator of transcription 6 antibody Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced antibody Signal Transducer And Activator Of Transcription 6 Nirs Variant 1 antibody Signal transducer and activator of transcription 6, interleukin 4 induced antibody STAT 6 antibody STAT interleukin4 induced antibody STAT, interleukin4 induced antibody Stat6 antibody STAT6_HUMAN antibody STAT6B antibody STAT6C antibody Transcription factor IL 4 STAT antibody

Abbreviation

STAT6

Swiss Prot

P42226 Human, P52633 Mouse

Cellular Locus

Cytoplasm, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within human STAT6 C terminal.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, IP, FC, IF-Tissue

Positive Control

Hela-si NT cell lysate, Hela-si STAT6 cell lysate, THP-1 cell lysate, Jurkat cell lysate, Raji cell lysate, HeLa cell lysate, MDA-MB-231 cell lysate, NIH/3T3 cell lysate, RAW264.7 cell lysate, human solitary fibrous tumor tissue, Hela, HepG2, NIH/3T3.

Concentration

1 mg/mL

Dilution

WB: 1:2,000 ;IF-Cell: 1:200-1:500 ;IHC-P: 1:3,000 ;IF-Tissue: 1:200 ;FC: 1:1,000 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 94 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes