Hsp90 beta Recombinant Rabbit Monoclonal Antibody [SY46-01]

About this product

The heat shock response was first described for Drosophila salivary gland cells and morphologically consists of a change in their polytene chromosome puffing patterns that involves de novo synthesis of a few proteins. Similar heat shock proteins were later discovered in bacterial chicken and mammalian cells, and have been subsequently studied in other organisms. A series of proteins including HSP 90, HSP 70, HSP 20-30 and ubiquitin are induced by insults such as temperature shock, chemicals and other environmental stress. A major function of HSP 90 and other HSPs is to act as molecular chaperones. HSP 90 forms a complex with glucocorticoid receptor (GR), rendering the non ligand-bound receptor transcriptionally inactive. HSP 90 binds the GR as a heterocomplex composed of either HSP 56 or Cyclophilin D, forming an aporeceptor comiplex. HSP 90 also exists as a dimer with other proteins such as p60/sti1 and p23, forming an apo-receptor complex with estrogen and androgen receptors.

Specifications

Catalog number

ET1605-56

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

90 kda heat shock protein beta HSP90 beta antibody D6S182 antibody FLJ26984 antibody Heat shock 84 kDa antibody Heat shock 90kD protein 1, beta antibody Heat shock 90kDa protein 1 beta antibody Heat shock protein 90 alpha family class B member 1 antibody Heat shock protein 90 kDa antibody Heat shock protein 90kDa alpha (cytosolic) class B member 1 antibody Heat shock protein 90kDa alpha family class B member 1 antibody Heat shock protein beta antibody Heat shock protein HSP 90 beta antibody Heat shock protein HSP 90-beta antibody HS90B_HUMAN antibody HSP 84 antibody HSP 90 antibody HSP 90 b antibody HSP 90b antibody HSP84 antibody HSP90 BETA antibody hsp90ab1 antibody HSP90B antibody HSPC2 antibody HSPCB antibody

Abbreviation

HSP 90, HSP 84, HSP90AB1

Swiss Prot

P08238 Human, P11499 Mouse, P34058 Rat

Cellular Locus

Cytoplasm, Melanosome,Nucleus,Secreted,Cell membrane,Dynein axonemal particle .

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human Hsp90 beta aa 485-724 / 724.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP, FC

Positive Control

HEK-293 cell lysate, HeLa cell lysate, A431 cell lysate, K-562 cell lysate, RAW264.7 cell lysate, PC-12 cell lysate, mouse heart tissue lysate, rat heart tissue lysate, human liver tissue lysate, mouse liver tissue lysate, rat liver tissue lysate, human kidney tissue lysate, mouse kidney tissue lysate, rat kidney tissue lysate, HeLa, NIH/3T3, human colon carcinoma tissue, human breast carcinoma tissue, human tonsil tissue.

Concentration

1 mg/mL

Dilution

WB: 1:5,000-1:20,000 ;IF-Cell: 1:1,000 ;IF-Tissue: 1:100-1:500 ;IHC-P: 1:400 ;FC: 1:500-1:1,000 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 83 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes