CD11c Recombinant Rabbit Monoclonal Antibody [SI19-06]

About this product

Integrin αX (CD11C, leukocyte surface antigen p150,95, CR4, Axb2) is a type 1 transmembrane protein that traditionally combines with β2 chain to form a leukocyte-specific integrin known as inactivated-C3b (iC3b) receptor 4 (CR4). Integrin αX/β2 shares similar properties of the αM/β2 integrin in mediating adherence of neutrophils and monocytes to stimulated endothelial cells, and in phagocytosis of complement coated particles. Abnormal expression of Integrin αX is characteristic of hairy cell leukemia (HCL) and is dependent upon activation of proto-oncogenes Ras and JunD. Proteins and DNA elements that influence transcription of Integrin αX include Sp1 and Sp1-like factors, AP-1 family, C/EBP, Oct-2 and PU.1. Integrin αX is present on monocyte derivative dendritic cells (DCs), macrophages and NK cells. Upon activation, DCs present in skin (Langerhans cells), lining of nose, lung, stomach, intestine and blood can migrate to lymphoid tissues and interact with T and B cells to initiate and shape the immune response.

Specifications

Catalog number

ET1606-19

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

95 alpha chain antibody 95 antibody CD 11c antibody CD11 antigen-like family member C antibody CD11c antibody CD11c antigen antibody Complement component 3 receptor 4 subunit antibody CR4 antibody Integrin alpha X antibody Integrin alpha X chain antibody Integrin alpha-X antibody Integrin aX antibody Integrin subunit alpha X antibody integrin, alpha X (antigen CD11C (p150), alpha polypeptide) antibody integrin, alpha X (complement component 3 receptor 4 subunit antibody ITAX_HUMAN antibody ITGAX antibody LEU M5 alpha subunit antibody Leu M5 antibody Leukocyte adhesion glycoprotein p150 95 alpha chain antibody Leukocyte adhesion glycoprotein p150 antibody Leukocyte adhesion receptor p150 95 antibody Leukocyte adhesion receptor p150 antibody Leukocyte surface antigen p150 95 alpha subunit antibody Leukocyte surface antigen p150 alpha subunit antibody Myeloid membrane antigen alpha subunit antibody p150 95 integrin alpha chain antibody p150 antibody p150/95 antibody SLEB6 antibody

Abbreviation

ITGAX

Swiss Prot

P20702 Human

Cellular Locus

Membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human CD11c aa 1,114-1,163 / 1,163 (Cytoplasmic).

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IP, mIHC

Positive Control

Human Hodgkin's lymphoma tissue, human spleen tissue, human lymph nodes tissue, human colon cancer tissue, human liver tissue, human cervical cancer, human tonsil.

Concentration

1 mg/mL

Dilution

WB: 1:500 ;IHC-P: 1:400-1:1,000 ;IP: Use at an assay dependent concentration. ;mIHC: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 128 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes