ATM Recombinant Rabbit Monoclonal Antibody [SI70-01]

About this product

The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy-termini that is not present in the PI 3- and PI 4-kinases. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiec-tases) in the conjunctivae of the eyes. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction.

Specifications

Catalog number

ET1606-20

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

A-T mutated antibody A-T mutated homolog antibody AT mutated antibody AT1 antibody ATA antibody Ataxia telangiectasia mutated antibody Ataxia telangiectasia mutated gene antibody Ataxia telangiectasia mutated homolog (human) antibody Ataxia telangiectasia mutated homolog antibody ATC antibody ATD antibody ATDC antibody ATE antibody ATM antibody ATM serine/threonine kinase antibody ATM_HUMAN antibody DKFZp781A0353 antibody MGC74674 antibody OTTHUMP00000232981 antibody Serine protein kinase ATM antibody Serine-protein kinase ATM antibody Serine/threonine-protein kinase ATM antibody Tefu antibody TEL1 antibody TEL1, telomere maintenance 1, homolog antibody TELO1 antibody Telomere fusion protein antibody

Abbreviation

A-T mutated

Swiss Prot

Q13315 Human,

Cellular Locus

Nucleus,Cytoplasm, cytoskeleton, microtubule organizing center, centrosome By Similarity.

Host

Rabbit

Species Reactivity

Human, Rat

Immunogen

Synthetic peptide within Human ATM aa 1,951-2,000 / 3,056.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P

Positive Control

HeLa cell lysate, A549 cell lysate, NCCIT cell lysate, HEK-293 cell lysate, CRC cell lysate, HeLa, human testis tissue, human tonsil tissue, rat colon tissue, human pancreas tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 351 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes