CD8 alpha Recombinant Rabbit Monoclonal Antibody [SI18-01]

About this product

The T cell receptor (TCR) is a heterodimer composed of either α and β or γ and δ chains. CD3 chains and the CD4 or CD8 (CD8-α and CD8-β) co-receptors are also required for efficient signal transduction through the TCR. The TCR is expressed on T helper and T cytotoxic cells that can be distinguished by their expression of CD4 and CD8 proteins; T helper cells express CD4 proteins and T cytotoxic cells display CD8 proteins. CD8s are cell surface glycoproteins that exist as two chain complex (αα or αβ) receptors that bind class I MHC molecules presented by the antigen-presenting cell (APC). A primary function of CD8 proteins is to facilitate antigen recognition by the TCR and to strengthen the avidity of the TCR-antigen interactions. An additional role for CD8-expressing T cells may be to maintain low levels of HIV expression.

Specifications

Catalog number

ET1606-31

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

alpha polypeptide (p32) antibody CD8 antibody CD8 antigen alpha polypeptide antibody CD8 antigen alpha polypeptide (p32) antibody CD8a antibody CD8A antigen antibody CD8A molecule antibody CD8A_HUMAN antibody Leu2 antibody Leu2 T lymphocyte antigen antibody Ly3 antibody LYT3 antibody MAL antibody OKT8 T cell antigen antibody OTTHUMP00000160760 antibody OTTHUMP00000160764 antibody OTTHUMP00000203528 antibody OTTHUMP00000203721 antibody p32 antibody T cell antigen Leu2 antibody T cell co receptor antibody T-cell surface glycoprotein CD8 alpha chain antibody T-lymphocyte differentiation antigen T8/Leu-2 antibody T8 T cell antigen antibody T8/Leu-2 T-lymphocyte differentiation antigen antibody

Abbreviation

CD8A, MAL

Swiss Prot

P01732 Human

Cellular Locus

Cell membrane, Secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human CD8 alpha aa 186-235 / 235.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, FC

Positive Control

THP-1 cell lysate, Jurkat cell lysate, PC-3M cell lysate, Hela, CRC, human spleen tissue, human lymph node tissue, human appendix tissue, Jurkat.

Concentration

1 mg/mL

Dilution

WB: 1:2,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:500-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 26 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes