Calmodulin Recombinant Rabbit Monoclonal Antibody [SJ16-09]

About this product

The level of intracellular calcium is tightly regulated in all eukaryotic cells. A modest increase in this level can result in a myriad of physiological responses, most of which are mediated by calmodulin (CaM), the universal calcium sensor. CaM directly modulates the activity of protein kinases and phosphatases, ion channels and nitric oxide synthetases. It is generally involved in such diverse processes as cell proliferation, endocytosis, cellular adhesion, protein turn over and smooth muscle contraction. CaM (calmodulin) is an acidic protein, 148 amino acids in length, with four helix-loop-helix calcium binding domains. In humans, 3 distinct genes have been identified (CALM1, CALM2 and CALM3); each encoding the identical protein. CALML3 (calmodulin-like 3, or calmodulin-related protein NB-1) shares significant sequence identity with CaM and it is suggested that it may competitively bind CaM substrates. Interestingly, CaM has been shown to associate with the carboxy terminus of the dystrophin gene product, implying that it may regulate its activity.

Specifications

Catalog number

ET1606-46

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9000-83-3

Product Name Alternative

CALM 1 antibody CALM 2 antibody CALM 3 antibody CALM antibody CALM_HUMAN antibody CALM1 antibody CALM2 antibody Calm3 antibody CALML2 antibody calmodulin 1 (phosphorylase kinase, delta) antibody Calmodulin 2 (phosphorylase kinase, delta) antibody Calmodulin 3 (phosphorylase kinase, delta) antibody Calmodulin antibody CaM antibody CAM I antibody CAM1 antibody CAM2 antibody CAM3 antibody CAMB antibody CAMC antibody CAMI antibody CAMII antibody CPVT4 antibody DD132 antibody FLJ99410 antibody LP7057 protein antibody PHKD antibody PHKD2 antibody PHKD3 antibody phosphorylase kinase delta antibody phosphorylase kinase, delta subunit antibody

Abbreviation

CaM, CALM1, CALM, CAM, CAM1

Swiss Prot

P0DP23 Human, P0DP24 Human, P0DP25 Human

Cellular Locus

Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Dog, Rat

Immunogen

Synthetic peptide within Human Calmodulin aa 100-149 / 149.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP

Positive Control

Rat brain tissue lysates, Hela, MCF-7, NIH/3T3, mouse brain tissue, mouse cerebellum tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:200 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

17 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes