Notch 1 Recombinant Rabbit Monoclonal Antibody [SJ205]

About this product

The LIN-12/notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. To date, four notch homologs have been identified in mammals and have been designated Notch 1, Notch 2, Notch 3 and Notch 4. The notch genes are expressed in a variety of tissues in both the embryonic and adult organism, suggesting that the genes are involved in multiple signaling pathways. The notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for notch include Jagged1, Jagged2 and Delta. Jagged can activate notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes. Jagged2 is thought to be involved in the development of various tissues whose development is dependent upon epithelial-mesenchymal interactions. Normal Delta expression is restricted to the adrenal gland and placenta. Delta expression has also been found in neuroendocrine tumors such as neuroblastomas and pheochromocytomas.

Specifications

Catalog number

ET1606-55

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9000-83-3

Product Name Alternative

9930111A19Rik antibody AOS5 antibody AOVD1 antibody hN1 antibody Lin-12 antibody LIN12 antibody Mis6 antibody Motch A antibody mT14 antibody Neurogenic locus notch homolog protein 1 antibody Neurogenic locus notch protein homolog antibody NICD antibody NOTC1_HUMAN antibody Notch 1 antibody Notch 1 intracellular domain antibody NOTCH antibody Notch gene homolog 1 (Drosophila) antibody Notch homolog 1, translocation-associated (Drosophila) antibody NOTCH, Drosophila, homolog of, 1 antibody notch1 antibody TAN1 antibody Translocation associated notch homolog antibody Translocation associated notch protein TAN 1 antibody Translocation-associated notch protein TAN-1 antibody xotch antibody

Abbreviation

Notch 1, hN1

Swiss Prot

P46531 Human, Q01705 Mouse

Cellular Locus

Cell membrane, Nucleus (intracellular domain).

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human Notch 1 aa 2,481-2,530 / 2,555.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP, FC

Positive Control

MDA-MB-231 cell lysate, THP-1 cell lysate, human pancreas tissue, mouse lung tissue, mouse pancreas tissue, Hela cell.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:2,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 273 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes