DNAJC15 Recombinant Rabbit Monoclonal Antibody [SY26-04]

About this product

The DnaJ family is one of the largest of all the chaperone families and has evolved with diverse cellular localization and functions. The presence of a J domain defines a protein as a member of the DnaJ family. DnaJ heat shock induced proteins are from the bacterium Escherichia coli and are under the control of the htpR regulatory protein. The DnaJ proteins play a critical role in the HSP 70 chaperone machine by interacting with HSP 70 to stimulate ATP hydrolysis. DnaJ proteins are important mediators of proteolysis and are involved in the regulation of protein degradation, exocytosis and endocytosis. MCJ (methylation-controlled J protein), also known as HSD18, DNAJD1 or DNAJC15, is a 150 amino acid ubiquitously expressed single-pass membrane protein containing one J domain. Localizing to the golgi apparatus and only present in vertebrates, MCJ may be associated with increased chemotherapeutic resistance in ovarian cancer by inducing expression of the Mdr drug transporter and preventing intracellular drug accumulation.

Specifications

Catalog number

ET1607-52

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Cell growth inhibiting gene 22 protein antibody Cell growth-inhibiting gene 22 protein antibody DJC15_HUMAN antibody DnaJ (Hsp40) homolog subfamily C member 15 antibody DNAJ domain containing antibody DnaJ homolog subfamily C member 15 antibody DNAJC15 antibody DNAJD1 antibody GIG22 antibody HSD18 antibody MCJ antibody Methylation controlled J protein antibody Methylation-controlled J protein antibody

Abbreviation

MCJ

Swiss Prot

Q9Y5T4 Human, Q78YY6 Mouse,

Cellular Locus

Mitochondrion inner membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human DNAJC15 aa 10-150 / 150.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

Human brain tissue lysates, mouse heart tissue lysates, human liver carcinoma tissue, human kidney tissue, mouse testis tissue, mouse kidney tissue, mouse heart tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 16 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes