MKLP1 Recombinant Rabbit Monoclonal Antibody [SY02-74]

About this product

KIF23 (also known as Kinesin-6, CHO1/MKLP1, C. elegans ZEN-4 and Drosophila Pavarotti) is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in two transcript variants encoding two different isoforms, better known as CHO1, the larger isoform and MKLP1, the smaller isoform. KIF23 is a plus-end directed motor protein expressed in mitosis, involved in the formation of the cleavage furrow in late anaphase and in cytokinesis. KIF23 is part of the centralspindlin complex that includes PRC1, Aurora B and 14-3-3 which cluster together at the spindle midzone to enable anaphase in dividing cells. In neuronal development KIF23 is involved in the transport of minus-end distal microtubules into dendrites and is expressed exclusively in cell bodies and dendrites.

Specifications

Catalog number

ET1607-63

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CHO 1 antibody CHO1 antibody KIF 23 antibody KIF23 antibody KIF23_HUMAN antibody Kinesin family member 23 antibody Kinesin like 5 antibody Kinesin like protein 5 antibody Kinesin like protein KIF 23 antibody Kinesin like protein KIF23 antibody Kinesin-like protein 5 antibody Kinesin-like protein KIF23 antibody KNS L5 antibody KNSL 5 antibody KNSL5 antibody Mitotic kinesin like 1 antibody Mitotic kinesin like protein 1 antibody Mitotic kinesin-like protein 1 antibody MKLP 1 antibody

Abbreviation

KIF23

Swiss Prot

Q02241 Human

Cellular Locus

Cytoplasm, Nucleus, Midbody.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human MKLP1 aa 801-850 / 960.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue

Positive Control

A549 cell lysates, RAW264.7 cell lysates, Hela, A549.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 110 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes