Bim Recombinant Rabbit Monoclonal Antibody [SU0318]

About this product

Bcl-2-like protein 11, commonly called BIM, is a protein that in humans is encoded by the BCL2L11 gene. The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X (L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1 (FoxO3a), which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.

Specifications

Catalog number

ET1608-14

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

BCL2 like 11 antibody B2L11_HUMAN antibody BAM antibody Bcl 2 interacting protein Bim antibody Bcl 2 related ovarian death agonist antibody Bcl-2-like protein 11 antibody BCL2 interacting mediator of cell death antibody BCL2 like 11 (apoptosis facilitator) antibody BCL2 like protein 11 antibody Bcl2-interacting mediator of cell death antibody Bcl2-L-11 antibody Bcl2l11 antibody BIM alpha6 antibody BIM antibody BIM beta6 antibody BIM beta7 antibody BimEL antibody BimL antibody BOD antibody

Abbreviation

Bcl2-L-11, BCL2L11

Swiss Prot

O43521 Human, O54918 Mouse

Cellular Locus

Endomembrane system, Mitochondrion.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Synthetic peptide within human Bim aa 1-40.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, IP, FC

Positive Control

Raji cell lysate, HeLa cell lysate, MCF7 cell lysate, RAW264.7 cell lysate, Hela, A431, HepG2, human breast carcinoma tissue, RAW264.7, MCF7.

Concentration

1 mg/mL

Dilution

WB: 1:5,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200 ;IP: Use at an assay dependent concentration. ;FC: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 22 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes