LGR5 Recombinant Rabbit Monoclonal Antibody [SU32-04] — image 1 of 3

Product details

LGR5 Recombinant Rabbit Monoclonal Antibody [SU32-04]

Catalog number ET1608-18

Price for ET1608-18

Size / count 100 µL

About this product

Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) also known as G-protein coupled receptor 49 (GPR49) or G-protein coupled receptor 67 (GPR67) is a protein that in humans is encoded by the LGR5 gene. It is a member of GPCR class A receptor proteins. R-spondin proteins are the biological ligands of LGR5. LGR5 is expressed across a diverse range of tissue such as in the muscle, placenta, spinal cord and brain and particularly as a biomarker of adult stem cells in certain tissues. LGR5 is a member of the Wnt signaling pathway. Although its ligand remains elusive, it has been shown that costimulation with R-spondin 1 and Wnt-3a induce increased internalization of LGR5. LGR5 also cointernalizes with LRP6 and FZD5 via a clathrin-dependent pathway to form a ternary complex upon Wnt ligand binding. Moreover, the rapid cointernalization of LRP6 by LGR5 induces faster rates of degradation for the former. LGR5 is crucial during embryogenesis as LGR null studies in mice incurred 100% neonatal mortality accompanied by several craniofacial distortions such as ankyloglossia and gastrointestinal dilation.

Specifications

Catalog number: ET1608-18
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: FEX antibody G protein coupled receptor 49 antibody G protein coupled receptor 67 antibody g protein-coupled receptor fex antibody G-protein coupled receptor 49 antibody G-protein coupled receptor 67 antibody G-protein coupled receptor HG38 antibody GPR 49 antibody GPR 67 antibody GPR49 antibody GPR67 antibody GRP 49 antibody GRP49 antibody HG 38 antibody HG38 antibody Leucine rich repeat containing G protein coupled receptor 5 antibody Leucine-rich repeat-containing G-protein coupled receptor 5 antibody LGR 5 antibody LGR5 antibody LGR5_HUMAN antibody MGC117008 antibody Orphan G protein coupled receptor HG38 antibody
Abbreviation: LGR5, GPR49, GPR67
Swiss Prot: O75473 Human, Q9Z1P4 Mouse
Cellular Locus: Cell membrane, Golgi apparatus, Membrane.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide within Human LGR5 aa 816-865 / 907.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IP
Positive Control: Mouse skeletal muscle tissue lysate, rat skeletal muscle tissue lysate, mouse spinal cord tissue lysate, human skeletal muscle tissue lysate, rat kidney tissue lysate, rat spinal cord tissue lysate, SH-SY5Y.
Concentration: 1 mg/mL
Dilution: WB: 1:5,000 ;IP: Use at an assay dependent concentration.
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 100 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for LGR5 Recombinant Rabbit Monoclonal Antibody [SU32-04]?

The catalog number for LGR5 Recombinant Rabbit Monoclonal Antibody [SU32-04] is ET1608-18.

What sizes are available for LGR5 Recombinant Rabbit Monoclonal Antibody [SU32-04]?

LGR5 Recombinant Rabbit Monoclonal Antibody [SU32-04] is available in the following size(s): 100 µL.

Is LGR5 Recombinant Rabbit Monoclonal Antibody [SU32-04] in stock?

LGR5 Recombinant Rabbit Monoclonal Antibody [SU32-04] is currently made to order / not held in immediate stock. Contact us for lead time.

What is LGR5 Recombinant Rabbit Monoclonal Antibody [SU32-04] used for?

Is this product covered by a money-back guarantee?

Yes, we guarantee a full refund or store credit if this product arrives damaged beyond usability, or has a genuine performance issue under proper usage and storage, provided you report it immediately with evidence. Claims after the expiration date or due to improper storage after receipt are excluded.

Can this product be used for diagnostic or therapeutic purposes?

No. This product, like all items we supply, is intended for research laboratory use only and must not be used for diagnostics, therapeutics, treatment, or consumption by humans or animals.

What is the shelf life of this product?

Shelf life and expiration dates vary by product and are shown on the product listing and label. Products used beyond their expiration date are not eligible for performance-related returns or refunds, so please check the lot number and expiry before use.