DARPP32 Recombinant Rabbit Monoclonal Antibody [SU0329]

About this product

Protein phosphatase 1 regulatory subunit 1B (PPP1R1B), also known as dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32), is a protein that in humans is encoded by the PPP1R1B gene. Midbrain dopaminergic neurons play a critical role in multiple brain functions, and abnormal signaling through dopaminergic pathways has been implicated in several major neurologic and psychiatric disorders. One well studied target for the actions of dopamine is DARPP32. In the densely dopamine- and glutamate-innervated rat caudate-putamen, DARPP32 is expressed in medium-sized spiny neurons that also express dopamine D1 receptors. DARPP-32 is critical for dopamine dependent striatal synaptic plasticity, possibly by serving as a dopamine-dependent gating mechanism for calcium/CaMKII signaling.

Specifications

Catalog number

ET1608-23

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

DARPP 32 antibody DARPP-32 antibody Dopamine and cAMP regulated neuronal phosphoprotein 32 antibody Dopamine and cAMP regulated neuronal phosphoprotein antibody Dopamine and cAMP regulated phosphoprotein antibody Dopamine and cAMP regulated phosphoprotein DARPP 32 antibody Dopamine and cAMP regulated phosphoprotein DARPP32 antibody Dopamine- and cAMP-regulated neuronal phosphoprotein antibody FLJ20940 antibody IPPD antibody Neuronal phosphoprotein DARPP 32 antibody PPP1R1B antibody PPR1B_HUMAN antibody Protein phosphatase 1 regulatory (inhibitor) subunit 1B antibody Protein phosphatase 1 regulatory inhibitor subunit 1B antibody Protein phosphatase 1 regulatory subunit 1B antibody

Abbreviation

PPP1R1B

Swiss Prot

Q9UD71 Human, Q60829 Mouse, Q6J4I0 Rat

Cellular Locus

Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human DARPP32 aa 1-94 / 204.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IP, FC, IHC-P, IHC-Fr

Positive Control

Mouse striatum tissue, mouse forebrain tissue, human brain tissue, human colon tissue, mouse brian tissue, mouse epididymis tissue, rat brian tissue, Human brain tissue lysate, Mouse brain tissue lysate, Rat brain tissue lysate, Rat hippocampus tissue lysate, SH-SY5Y, MCF-7, Hela.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;IF-Cell: 1:50-1:200 ;FC: 1:50-1:100 ;IHC-P: 1:500-1:1,000 ;IHC-Fr: 1:500

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 23 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes