PARP1 Recombinant Rabbit Monoclonal Antibody [SU03-68] — image 1 of 3

Product details

PARP1 Recombinant Rabbit Monoclonal Antibody [SU03-68]

Catalog number ET1608-56

Price for ET1608-56

Size / count 100 µL

About this product

The main role of PARP (found in the cell nucleus) is to detect and initiate an immediate cellular response to metabolic, chemical, or radiation-induced single-strand DNA breaks (SSB) by signaling the enzymatic machinery involved in the SSB repair. Once PARP detects a SSB, it binds to the DNA, undergoes a structural change, and begins the synthesis of a polymeric adenosine diphosphate ribose (poly (ADP-ribose) or PAR) chain, which acts as a signal for the other DNA-repairing enzymes. Target enzymes include DNA ligase III (LigIII), DNA polymerase beta (polβ), and scaffolding proteins such as X-ray cross-complementing gene 1 (XRCC1). After repairing, the PAR chains are degraded via Poly (ADP-ribose) glycohydrolase (PARG). PARP enzymes are essential in a number of cellular functions, including expression of inflammatory genes: PARP1 is required for the induction of ICAM-1 gene expression by cardiac myocytes and smooth muscle cells, in response to TNF.

Specifications

Catalog number: ET1608-56
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase) antibody ADP ribosyltransferase diphtheria toxin like 1 antibody ADP ribosyltransferase NAD (+) antibody ADPRT 1 antibody ADPRT antibody ADPRT1 antibody ARTD1 antibody msPARP antibody NAD (+) ADP ribosyltransferase 1 antibody NAD (+) ADP-ribosyltransferase 1 antibody pADPRT 1 antibody pADPRT1 antibody PARP 1 antibody PARP antibody PARP-1 antibody PARP1 antibody PARP1_HUMAN antibody Poly (ADP ribose) polymerase 1 antibody poly (ADP ribose) polymerase family, member 1 antibody Poly [ADP-ribose] polymerase 1 antibody Poly (ADP ribose) polymerase antibody poly (ADP ribose) synthetase antibody poly (ADP ribosyl)transferase antibody Poly[ADP ribose] synthetase 1 antibody Poly[ADP-ribose] synthase 1 antibody PPOL antibody
Abbreviation: PARP-1, ARTD1, ADPRT 1, PARP1
Swiss Prot: P09874 Human, P11103 Mouse, P27008 Rat
Cellular Locus: Nucleus, nucleolus, chromosome.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide within N-terminal human PARP1.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IF-Cell, IF-Tissue, IHC-P, FC
Positive Control: A549 cell lysate, Jurkat cell lysate, Hela cell lysate, HeLa, human spleen tissue, mouse large intestine tissue, human breast carcinoma tissue, NIH/3T3 cell lysate, C2C12 cell lysate, PC-12 cell lysate.
Concentration: 1 mg/mL
Dilution: WB: 1:2,000 ;IF-Cell: 1:500 ;IF-Tissue: 1:50-1:800 ;IHC-P: 1:500-1:4,000 ;FC: 1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 113 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for PARP1 Recombinant Rabbit Monoclonal Antibody [SU03-68]?

The catalog number for PARP1 Recombinant Rabbit Monoclonal Antibody [SU03-68] is ET1608-56.

What sizes are available for PARP1 Recombinant Rabbit Monoclonal Antibody [SU03-68]?

PARP1 Recombinant Rabbit Monoclonal Antibody [SU03-68] is available in the following size(s): 100 µL.

Is PARP1 Recombinant Rabbit Monoclonal Antibody [SU03-68] in stock?

PARP1 Recombinant Rabbit Monoclonal Antibody [SU03-68] is currently made to order / not held in immediate stock. Contact us for lead time.

What is PARP1 Recombinant Rabbit Monoclonal Antibody [SU03-68] used for?

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.

Does this product need any special customs documentation to be imported to my country?

If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.

What buffer is this product supplied in?

The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.