Phospho-p53 (S376) Recombinant Rabbit Monoclonal Antibody [ST0440]

Catalog number ET1609-14

Price for ET1609-14

Size / count 100 µL

About this product

p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.

Specifications

Catalog number: ET1609-14
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: Antigen NY-CO-13 antibody BCC7 antibody Cellular tumor antigen p53 antibody FLJ92943 antibody LFS1 antibody Mutant tumor protein 53 antibody p53 antibody p53 tumor suppressor antibody P53_HUMAN antibody Phosphoprotein p53 antibody Tp53 antibody Transformation related protein 53 antibody TRP53 antibody Tumor protein 53 antibody Tumor protein p53 antibody Tumor suppressor p53 antibody
Abbreviation: TP53
Swiss Prot: P04637 Human
Cellular Locus: Cytoplasm, Nucleus, Endoplasmic reticulum, Mitochondrion matrix.
Host: Rabbit
Species Reactivity: Human, Mouse
Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser376 of Human p53 aa 344-393 / 393.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB
Positive Control: HEK-293 treated with 200nM Calyculin A and 1uM Okadaic Acid for 1 hours whole cell lysate, RAW264.7 treated with 200nM Calyculin A and 1uM Okadaic Acid for 1 hours whole cell lysate.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 53 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Phospho-p53 (S376) Recombinant Rabbit Monoclonal Antibody [ST0440]?

The catalog number for Phospho-p53 (S376) Recombinant Rabbit Monoclonal Antibody [ST0440] is ET1609-14.

What sizes are available for Phospho-p53 (S376) Recombinant Rabbit Monoclonal Antibody [ST0440]?

Phospho-p53 (S376) Recombinant Rabbit Monoclonal Antibody [ST0440] is available in the following size(s): 100 µL.

Is Phospho-p53 (S376) Recombinant Rabbit Monoclonal Antibody [ST0440] in stock?

Phospho-p53 (S376) Recombinant Rabbit Monoclonal Antibody [ST0440] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Phospho-p53 (S376) Recombinant Rabbit Monoclonal Antibody [ST0440] used for?

Is this product covered by a money-back guarantee?

Yes, we guarantee a full refund or store credit if this product arrives damaged beyond usability, or has a genuine performance issue under proper usage and storage, provided you report it immediately with evidence. Claims after the expiration date or due to improper storage after receipt are excluded.

Can this product be used for diagnostic or therapeutic purposes?

No. This product, like all items we supply, is intended for research laboratory use only and must not be used for diagnostics, therapeutics, treatment, or consumption by humans or animals.

What is the shelf life of this product?

Shelf life and expiration dates vary by product and are shown on the product listing and label. Products used beyond their expiration date are not eligible for performance-related returns or refunds, so please check the lot number and expiry before use.