Androgen receptor Recombinant Rabbit Monoclonal Antibody [ST0453]

About this product

Androgens exhibit a wide range of effects on the development, maintenance and regulation of male phenotype and male reproductive physiology. The androgen receptor (AR) is a member of the steroid superfamily of ligand-dependent transcription factors. ARs bind the two biologically active androgens, testosterone (T) and dihydrotestosterone (DHT), with high and nearly identical affinities; however, the rates of association and dissociation of T are about three times more rapid than those of DHT. This difference has resulted in speculation as to whether these differences in binding kinetics could account for the different physiological effects of T and DHT. A striking feature of AR is its rapid degradation in the absence of ligand. It is now well established that androgen binding results in an at least six-fold increase in androgen stability and that ligand-induced stabilization of AR is highly androgen- specific.

Specifications

Catalog number

ET1609-18

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

AIS antibody ANDR_HUMAN antibody Androgen nuclear receptor variant 2 antibody Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) antibody Androgen receptor antibody androgen receptor splice variant 4b antibody AR antibody AR8 antibody DHTR antibody Dihydro testosterone receptor antibody Dihydrotestosterone receptor (DHTR) antibody Dihydrotestosterone receptor antibody HUMARA antibody HYSP1 antibody KD antibody Kennedy disease (KD) antibody NR3C4 antibody Nuclear receptor subfamily 3 group C member 4 (NR3C4) antibody Nuclear receptor subfamily 3 group C member 4 antibody SBMA antibody SMAX1 antibody Spinal and bulbar muscular atrophy (SBMA) antibody Spinal and bulbar muscular atrophy antibody Testicular Feminization (TFM) antibody TFM antibody

Abbreviation

AR

Swiss Prot

P10275 Human

Cellular Locus

Nucleus, Cytoplasm.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human Androgen receptor aa 595-644 / 644 (P10275-3).

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB

Positive Control

22RV1 cell lysates.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 99 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes