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Product details

GRK2 Recombinant Rabbit Monoclonal Antibody [ST05-60]

Catalog number ET1609-72

Price for ET1609-72

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Size / count 100 µL

About this product

Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonist-mediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messenger-regulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1), two forms of beta-adrenergic receptor kinase: GRK 2 (betaARK, betaARK1) and GRK 3 (betaARK2), IT-11 (GRK 4), GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.

Specifications

Catalog number
ET1609-72
Size / count
100 µL
Dry ice
No
Hazardous
No
Discontinued
No
CAS Number
9000-83-3
Product Name Alternative
ADRBK1 antibody Adrenergic beta receptor kinase 1 antibody ARBK1_HUMAN antibody BARK antibody BARK1 antibody Beta adrenergic receptor kinase 1 antibody Beta ARK 1 antibody Beta ARK1 antibody Beta-adrenergic receptor kinase 1 antibody Beta-ARK-1 antibody FLJ16718 antibody G protein coupled receptor kinase 2 antibody G-protein coupled receptor kinase 2 antibody GRK2 antibody
Abbreviation
Beta-ARK-1, ADRBK1, BARK, BARK1, GRK2
Swiss Prot
P25098 Human, Q99MK8 Mouse, P26817 Rat
Cellular Locus
Cell membrane, Cytoplasm.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within Human GRK2 aa 640-689 / 689.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P
Positive Control
HCT 116 cell lysate, Raji cell lysate, RAW264.7 cell lysate, Mouse spleen tissue lysate, Rat spleen tissue lysate, rat brain tissue, rat spleen tissue, human tonsil tissue, human spleen tissue, mouse brain tissue, mouse spleen tissue.
Concentration
1 mg/mL
Dilution
WB: 1:1,000-1:2,000 ;IHC-P: 1:200-1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 80 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes

Frequently Asked Questions

What is the catalog number for GRK2 Recombinant Rabbit Monoclonal Antibody [ST05-60]?

The catalog number for GRK2 Recombinant Rabbit Monoclonal Antibody [ST05-60] is ET1609-72.

What sizes are available for GRK2 Recombinant Rabbit Monoclonal Antibody [ST05-60]?

GRK2 Recombinant Rabbit Monoclonal Antibody [ST05-60] is available in the following size(s): 100 µL.

Is GRK2 Recombinant Rabbit Monoclonal Antibody [ST05-60] in stock?

GRK2 Recombinant Rabbit Monoclonal Antibody [ST05-60] is currently made to order / not held in immediate stock. Contact us for lead time.

What is GRK2 Recombinant Rabbit Monoclonal Antibody [ST05-60] used for?

Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonist-mediated desensitization, involves phosphorylation of the receptor by two

Do you ship this product with dry ice?

Some products, including certain cell lines and biologics, require dry ice for transportation, which carries an additional fee shown clearly in your quotation. Dry ice delivery isn’t always possible to every destination due to transit time or local restrictions, so we check feasibility in advance and you must store the goods at the correct temperature the moment they arrive.

Is this product species cross-reactive?

Cross-reactivity data, based on available testing, is listed under the reactivity section of the datasheet. Contact us if you need reactivity confirmed for a species not listed.

Is there an additional fee for hazardous or dry ice shipping of this product?

Yes, if this product requires dry ice or is classed as hazardous for transport, the additional fee will be explicitly shown in your quotation before you confirm the order, so there are no surprise charges later.

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