Acetyl CoA Carboxylase 1 (ACC1) Recombinant Rabbit Monoclonal Antibody [ST53-08]

About this product

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACCα (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACCβ (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACCα is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the enzyme’s short-term regulatory mechanism. The gene encoding ACCα maps to human chromosome 17 and encodes a form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACCβ is homologous to that of the ACCα, except for an additional peptide of about 150 amino acids at the N-terminus.

Specifications

Catalog number

ET1609-77

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

ACAC antibody ACACA antibody ACACA_HUMAN antibody ACC alpha antibody ACC antibody ACC-alpha antibody ACC1 antibody ACCA antibody Acetyl CoA carboxylase 1 antibody Acetyl CoA carboxylase alpha antibody Acetyl Coenzyme A carboxylase alpha antibody Biotin carboxylase antibody COA1 antibody COA2 antibody HACC275 antibody OTTHUMP00000164069 antibody OTTHUMP00000164070 antibody OTTHUMP00000164076 antibody OTTHUMP00000240532 antibody

Abbreviation

ACAC, ACC1, ACCA,ACACA

Swiss Prot

Q13085 Human, Q5SWU9 Mouse, P11497 Rat

Cellular Locus

Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human ACC1 aa 382-427 / 2346.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

HeLa cell lysate, HepG2 cell lysate, HEK-293 cell lysate, A549 cell lysate, C2C12 cell lysate, RAW264.7 cell lysate, C6 cell lysate, human kidney tissue, mouse placenta tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:2,000 ;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 266 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes