p73 Recombinant Rabbit Monoclonal Antibody [ST05-76] — image 1 of 3

Product details

p73 Recombinant Rabbit Monoclonal Antibody [ST05-76]

Catalog number ET1609-80

Price for ET1609-80

Size / count 100 µL

About this product

The p53 gene is a widely studied anti-oncogene, or tumor suppressor gene. The p53 gene product can act as a negative regulator of cell growth in response to DNA damage. Mutations and allelic loss of the p53 gene have been associated with malignant transformation in a wide variety of human tumors. p53 shares considerable sequence similarity with p73, a gene that maps to a region in chromosome 1 that is frequently deleted in neuroblastomas. However, p73 does not appear to be activated by DNA damaging agents. The p73 isoform p73α inhibits drug-induced apoptosis in small cell lung carcinoma cells, while the p73 isoform p73β promotes it. p73α also prevents Bax activation, mitochondrial dysfunction, caspase activation and is able to reduce apoptosis induced by the BH3-only protein PUMA (p53 upregulated modulator of apoptosis). There is an equilibrium between p73α and p73β, demonstrated by the fact that p73α inhibits the pro-apoptotic effect of p73β.

Specifications

Catalog number: ET1609-80
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: p53 like transcription factor antibody p53 related protein antibody p53-like transcription factor antibody p53-related protein antibody p73 antibody P73_HUMAN antibody TP73 antibody Tumor protein p73 antibody
Abbreviation: TP73, P73
Swiss Prot: O15350 Human, Q9JJP2 Mouse
Cellular Locus: Cytoplasm, Nucleus.
Host: Rabbit
Species Reactivity: Human, Mouse
Immunogen: Recombinant protein within Human P73 aa 6-118 / 636.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IF-Cell, IF-Tissue, IHC-P
Positive Control: 293 cell lysates, MCF-7, human kidney tissue, mouse skin tissue, mouse kidney tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:2,000;IF-Cell: 1:50-1:200;IF-Tissue: 1:50-1:200;IHC-P: 1:50-1:200
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: 70 kDa (12 isoforms)
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for p73 Recombinant Rabbit Monoclonal Antibody [ST05-76]?

The catalog number for p73 Recombinant Rabbit Monoclonal Antibody [ST05-76] is ET1609-80.

What sizes are available for p73 Recombinant Rabbit Monoclonal Antibody [ST05-76]?

p73 Recombinant Rabbit Monoclonal Antibody [ST05-76] is available in the following size(s): 100 µL.

Is p73 Recombinant Rabbit Monoclonal Antibody [ST05-76] in stock?

p73 Recombinant Rabbit Monoclonal Antibody [ST05-76] is currently made to order / not held in immediate stock. Contact us for lead time.

What is p73 Recombinant Rabbit Monoclonal Antibody [ST05-76] used for?

How do I reconstitute this lyophilized product?

Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.

What is the recommended incubation time for this antibody?

A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.

What should I check when this product first arrives?

Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.