JNK2 Recombinant Rabbit Monoclonal Antibody [SC05-85]

About this product

c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield 10 isoforms through alternative mRNA splicing, including JNK1α1, JNK1β1, JNK2α1, JNK2β1, and JNK3α1, which represent the p46 isoforms, and JNK1α2, JNK1β2, JNK2α2, JNK2β2, and JNK3β2, which represent the p54 isoforms.JNKs coordinate cell responses to stress and influence regulation of cell growth and transformation. The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun, and other signaling kinases, including MEKK1 and p38.

Specifications

Catalog number

ET1610-11

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

c Jun kinase 2 antibody C Jun N terminal kinase 2 antibody c-Jun N-terminal kinase 2 antibody JNK 55 antibody JNK-55 antibody JNK2 alpha antibody JNK2 antibody JNK2 beta antibody JNK2A antibody JNK2alpha antibody JNK2B antibody JNK2BETA antibody Jun kinase antibody MAP kinase 9 antibody MAPK 9 antibody Mapk9 antibody Mitogen activated protein kinase 9 antibody Mitogen-activated protein kinase 9 antibody MK09_HUMAN antibody P54a antibody p54aSAPK antibody PRKM9 antibody Protein kinase, mitogen-activated, 9 antibody SAPK alpha antibody SAPK antibody SAPK1a antibody Stress activated protein kinase 1a antibody Stress-activated protein kinase JNK2 antibody

Abbreviation

MAP kinase 9, MAPK 9, SAPK1a, JNK2, PRKM9, SAPK1A

Swiss Prot

P45984 Human, Q9WTU6 Mouse, P49186 Rat

Cellular Locus

Cytoplasm, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human JNK2 aa 341-394 / 424.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, IP, FC

Positive Control

SHG-44 cell lysates, Hela, MCF-7, SHG-44, mouse brain tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 48/44 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes