Cytokeratin 16 Recombinant Rabbit Monoclonal Antibody [SC52-09]

About this product

Cytokeratins comprise a diverse group of intermediate filament proteins that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. The cytokeratin proteins play a critical role in differentiation, as well as tissue specialization and function, to maintain the overall structural integrity of epithelial cells. Cytokeratins are also useful markers in identifying the origin of metastatic tumors. Cytokeratin 16 is expressed in benign stratified squamous epithelium and squamous cell carcinoma of the head and neck, as well as luminal cells of mammary gland and sweat ducts. It is absent in noninvasive breast carcinomas and normal breast tissue. Mutations in the Cytokeratin 16 gene cause various diseases, including pachyonychia congenita type 1 (PC1), nonepidermolytic palmoplantar keratoderma (NEPPK) and unilateral palmoplantar verrucous nevus (UPVN).

Specifications

Catalog number

ET1610-17

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CK 16 antibody CK-16 antibody CK16 antibody Cytokeratin-16 antibody Cytokeratin16 antibody FNEPPK antibody Focal non epidermolytic palmoplantar keratoderma antibody K 16 antibody K16 antibody K1C16_HUMAN antibody K1CP antibody Keratin 1 type I antibody Keratin 16 antibody Keratin antibody Keratin type I cytoskeletal 16 antibody Keratin-16 antibody Keratin16 antibody KRT 16 antibody Krt16 antibody KRT16A antibody NEPPK antibody PC1 antibody type I cytoskeletal 16 antibody

Abbreviation

CK-16, K16

Swiss Prot

P08779 Human

Cellular Locus

Cytoskeleton, intermediate filament, cytosol, extracellular exosome, nucleus.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within human Cytokeratin 16 aa 27-75 / 473.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, FC

Positive Control

HeLa cell lysate, HaCaT cell lysate, HepG2 cell lysate, MCF7 cell lysate, A431, human esophagus tissue, human tonsil tissue, human lung carcinoma tissue, human breast carcinoma tissue, human breast tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IF-Cell: 1:100 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:1,500 ;FC: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 51 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes