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![Prion Protein (PrP) Recombinant Rabbit Monoclonal Antibody [SC57-05] — image 1 of 3](https://cdn.genprice.uk/products/992/68dd1c8c061270361ea81a1c/imageurl/et1610-27.webp)
Product details
Catalog number ET1610-27
Price for ET1610-27
Size / count 100 µL
Prion diseases, or transmissible spongiform encephalopathies (TSEs), are manifested as genetic, infectious or sporadic, lethal neurodegenerative disorders involving alterations of the prion protein (PrP). Characteristic of prion diseases, cellular PrP (PrPc) is converted to the disease form, PrPSc, through alterations in the protein folding conformations. PrPc is constitutively expressed in normal adult brain and is sensitive to proteinase K digestion, while the altered PrPSc conformation is resistant to proteases, resulting in a distinct molecular mass after PK treatment. Consistent with the transient infection process of prion diseases, incubation of PrPc with PrPSc both in vitro and in vivo produces PrPc that is resistant to protease degradation. Infectious PrPSc is found at high levels in the brains of animals affected by TSEs, including scrapie in sheep, BSE in cattle and Cruetzfeldt-Jakob disease in humans.
The catalog number for Prion Protein (PrP) Recombinant Rabbit Monoclonal Antibody [SC57-05] is ET1610-27.
Prion Protein (PrP) Recombinant Rabbit Monoclonal Antibody [SC57-05] is available in the following size(s): 100 µL.
Prion Protein (PrP) Recombinant Rabbit Monoclonal Antibody [SC57-05] is currently made to order / not held in immediate stock. Contact us for lead time.
Prion diseases, or transmissible spongiform encephalopathies (TSEs), are manifested as genetic, infectious or sporadic, lethal neurodegenerative disorders involving alterations of the prion protein (PrP). Characteristic of prion diseases, cellular PrP (PrPc) is converted to the disease form, PrPSc,
The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.
A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.
Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.
